Evidence map›Paper›PMID 41013639›Full record

ArticleStem cell research & therapy2025

Single-cell RNA sequencing of endometrium uncovers dynamic characteristics and dysregulation of perivascular CD9

Binfa Liang, Lingbin Qi, Mingye Chen, Canrong Mai, Lianghui Diao, Lijun Ding, Tao Zhang, Xian Chen

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In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Binfa Liang *Shenzhen Key Laboratory of Reproductive Immunology for Peri- implantation, Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen Zhongshan Obstetrics and Gynecology Hospital (formerly Shenzhen Zhongshan Urology Hospital), Shenzhen, China.
Lingbin Qi *Department of Reproductive Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Mingye ChenShenzhen Key Laboratory of Reproductive Immunology for Peri- implantation, Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen Zhongshan Obstetrics and Gynecology Hospital (formerly Shenzhen Zhongshan Urology Hospital), Shenzhen, China.
Canrong MaiShenzhen Key Laboratory of Reproductive Immunology for Peri- implantation, Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen Zhongshan Obstetrics and Gynecology Hospital (formerly Shenzhen Zhongshan Urology Hospital), Shenzhen, China.
Lianghui DiaoShenzhen Key Laboratory of Reproductive Immunology for Peri- implantation, Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen Zhongshan Obstetrics and Gynecology Hospital (formerly Shenzhen Zhongshan Urology Hospital), Shenzhen, China.
Lijun DingCenter for Reproductive Medicine and Obstetrics and Gynecology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, China.
Tao ZhangDepartment of Obstetrics and Gynecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Xian ChenShenzhen Key Laboratory of Reproductive Immunology for Peri- implantation, Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen Zhongshan Obstetrics and Gynecology Hospital (formerly Shenzhen Zhongshan Urology Hospital), Shenzhen, China. x_chen2022@163.com.ORCID http://orcid.org/0009-0000-0360-5003

Funding

National Natural Science Foundation of China 82401975Shenzhen Medical Research Fund A2403029Shenzhen Science and Technology Program JCYJ20220818103207016the Basic and Applied Basic Research Foundation of Guangdong 2024A1515010478
6 · The paper itself

Abstract

backgroundThin endometrium (TE) has been widely recognized as a critical cause of various obstetric and gynecological conditions. Although the role of stem cells in endometrial functions and their pathologies has been suggested, the identity and molecular mechanisms of such stem cells remain unclear.

methodsData analysis of a publicly available single-cell RNA sequencing (scRNA-seq) was performed to unravel the cellular and molecular characteristics of endometrial CD9

resultsA total of 59,770 cells were grouped into 13 distinct clusters in normal proliferative, secretory endometrium, and thin endometrium. Our findings revealed that perivascular CD9

conclusionsOur study provides potential molecular mechanisms underpinning perivascular CD9

Indexed as

EndometriumSingle-Cell AnalysisTetraspanin 29AdultCell DifferentiationCell ProliferationFemaleHumansSequence Analysis, RNAStem CellsCD9 protein, humanTetraspanin 29Endometrial progenitor cellsPerivascular CD9+ SUSD2+ cellsSingle-cell RNA sequencingThin endometrium

Identifiers

PMID41013639
PMCPMC12465366

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.