Evidence map›Paper›PMID 41013574›Full record

ArticleJournal of neuroinflammation2025

LncBADR promotes T cell-mediated autoimmunity by binding Mccc1 and Pcca to regulate BCAAs degradation.

Yanting Lei, Jing Yu, Xinrui Huo, Zhaoying Li, Jing Wang, Yixiang Jiang, Ying Yu, Yan Huang, Wenkang Jiang, Jiangtian Tian and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yanting LeiDepartment of Neurobiology, Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, School of Basic Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Jing YuDepartment of Neurobiology, Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, School of Basic Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Xinrui HuoDepartment of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100000, China.
Zhaoying LiThe Key Laboratory of Myocardial Ischemia, The Second Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Jing WangDepartment of Neurobiology, Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, School of Basic Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Yixiang JiangDepartment of Neurobiology, Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, School of Basic Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Ying YuDepartment of Clinical Laboratory, Jingjiang People's Hospital, Jingjiang, 214500, Jiangsu, China.
Yan HuangDepartment of Neurobiology, Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, School of Basic Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Wenkang JiangDepartment of Neurobiology, Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, School of Basic Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Jiangtian TianThe Key Laboratory of Myocardial Ischemia, The Second Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Dan KongDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Yumei LiuDepartment of Neurobiology, Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, School of Basic Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Xijun LiuDepartment of Neurobiology, Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, School of Basic Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Xiujuan LangDepartment of Neurobiology, Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, School of Basic Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Hulun LiDepartment of Neurobiology, Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, School of Basic Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, China. lihl@hrbmu.edu.cn.
Bo SunDepartment of Neurobiology, Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, School of Basic Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, China. sunbo72022@163.com.

Funding

National Natural Science Foundation of China 81870955National Natural Science Foundation of China 82271845Natural Science Foundation of Heilongjiang Province LH2022H004"Pandeng Program" of Harbin Medical University Cancer Hospital PDYS2024-08"XingLian" Outstanding Youth Foundation of Harbin Medical University 2024-202026
6 · The paper itself

Abstract

T cell dysfunction is a pivotal driving factor in autoimmune diseases, yet its underlying regulatory mechanisms remain incompletely understood. The role of long non-coding RNAs (lncRNAs) in immune regulation has gradually been recognized, although their functional mechanisms in T cells remain elusive. This study focuses on lncBADR (LncRNA Branched-chain Amino acids Degradation Regulator), elucidating its mechanism by which it regulates branched-chain amino acids (BCAAs) metabolism to influence T cell effector functions. Mice with specific knockout of lncBADR (T cell

Indexed as

Amino Acids, Branched-ChainAutoimmunityEncephalomyelitis, Autoimmune, ExperimentalRNA, Long NoncodingT-LymphocytesAnimalsFemaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionAmino Acids, Branched-ChainRNA, Long NoncodingBCAAs degradationExperimental autoimmune encephalomyelitisLncBADRmTOR-Stat1 pathwayT cells

Identifiers

PMID41013574
PMCPMC12465721

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.