TERT promoter C250T mutation in a recurrent cervical chordoid meningioma: a unique case report.

Xuanbo Shao, Zhuofan Xu, Penghao Liu, Teng Zhang, Yang Feng, Shaxi Zhu, Zan Chen, Wanru Duan

Abstract readCase Reports

In one paragraph

Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xuanbo Shao *Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing, 100053, China.

Zhuofan Xu *Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing, 100053, China.ORCID http://orcid.org/0000-0002-6481-1238

Penghao LiuDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing, 100053, China.ORCID http://orcid.org/0000-0002-9100-1580

Teng ZhangDepartment of Orthopaedics and Traumatology, Medicine School, The University of Hong Kong, Hong Kong, China.

Yang FengDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing, 100053, China.

Shaxi ZhuDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing, 100053, China.

Zan ChenDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing, 100053, China.ORCID http://orcid.org/0000-0002-0104-115X

Wanru DuanDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing, 100053, China. duanwanru@xwhosp.org.ORCID http://orcid.org/0000-0003-4751-3666

Funding

Beijing Municipal Science & Technology Commission No. L232141Ministry of Science & Technology of the People's Republic of China. No. 2023YFC2509700

6 · The paper itself

Abstract

Chordoid meningioma (CM) is an uncommon histological variant of meningioma, typically found intracranially. Intraspinal occurrences, particularly in the cervical region, are exceedingly rare. We report a unique case of a 73-year-old male with cervical spinal CM who experienced tumor recurrence two years after gross total resection (GTR). Histopathological analysis confirmed the recurrence as anaplastic meningioma with telomerase reverse transcriptase (TERT) promoter C250T mutation, CNS WHO Grade 3-marking the first documented association of this mutation with spinal CM. This case underscores the diagnostic, molecular, and prognostic complexities of spinal CM and highlights the critical role of TERT promoter mutation in tumor behavior and classification.

Indexed as

Meningeal NeoplasmsMeningiomaMutationNeoplasm Recurrence, LocalPromoter Regions, GeneticTelomeraseAgedCervical VertebraeHumansMalePrognosisTelomeraseTERT protein, humanChordoidMeningiomaSpineTERT

Identifiers

PMID41013491

DOI10.1186/s12957-025-04003-w

PMCPMC12466048

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.