Trial reportJournal of neuroengineering and rehabilitation2025
Enhanced episodic memory and LTP-like plasticity in subjective cognitive decline following 10-Hz repetitive transcranial magnetic stimulation.
Trial report in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of transcranial magnetic stimulation for mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials.Frontiers in neurologyPooled it
- Progress in non-invasive neuromodulation based on consciousness-related neural circuits: a narrative review.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundSubjective cognitive decline (SCD) is a self-perceived cognitive complaint in the absence of objective impairment, representing an at-risk state along the continuum of cognitive aging. High-frequency repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (L-DLPFC) has shown cognitive benefits in Alzheimer's disease (AD), yet its effects on cognitive functions in SCD remain largely unexplored.
objectiveTo evaluate the effects of 10-Hz rTMS over the L-DLPFC in individuals with SCD on cognitive functions and long-term potentiation (LTP)-like plasticity, indexed by changes in motor evoked potential (MEP) following intermittent theta burst stimulation, and examine the relationship between brain plasticity and cognitive outcomes.
methodsIn this randomized, sham-controlled trial, 42 individuals with SCD received 20 sessions of either active or sham 10-Hz rTMS (n = 21 per group) over four weeks. The primary outcome was delayed episodic memory, evaluated using the Auditory Verbal Learning Test-Huashan version (AVLT-H). Secondary outcomes included additional cognitive measures and MEP amplitudes at baseline and at 5 (T
resultsThe rTMS group exhibited significant improvements in both delayed episodic memory (AVLT-N5) and MEP amplitudes at T
conclusionsThese findings provide the first evidence for enhanced delayed episodic memory and LTP-like plasticity in individuals with SCD following 10-Hz rTMS over the L-DLPFC, suggesting a potential role of LTP-like plasticity in elucidating the neurophysiological correlates of cognitive improvements for SCD.
trial registrationThe study design and analysis plan were preregistered on September 7th, 2023 at Chinese Clinical Trial Registry (No. ChiCTR2300075517).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.