Observational studyRespiratory research2025
Acute COPD exacerbation despite triple inhaled therapy: a molecular insight - TripleEx study.
Observational study in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04638920 (Molecular Breath Print of COPD Patients With Exacerbations Despite Triple Inhalational Therapy), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molecular Breath Print of COPD Patients With Exacerbations Despite Triple Inhalational Therapy (TripleEX)
Who cites it
1 citing paper in PubMed.
- Anemia and hemoglobin thresholds of 12.5 and 13.0 g/dL are associated with distinct cardiovascular and all-cause mortality risks in COPD.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by persistent airflow limitation and acute exacerbations (AECOPD), which accelerate disease progression. Although triple inhaled therapy is recommended for patients with severe COPD and frequent AECOPD, some patients continue to experience exacerbations. The mechanisms behind this remain unclear. Exhaled breath analysis has the potential to unravel molecular changes during AECOPD, thereby adding to the understanding of molecular drivers for AECOPD. This study aimed to investigate metabolic changes in exhaled breath during AECOPD compared to stable state.
methodsIn COPD patients treated with triple inhaled therapy we conducted real time breath analysis during AECOPD and subsequent stable state. Molecular breath patterns were compared between AECOPD and stable state by pathway enrichment analysis. Minimum description length model was used to build a feature based prediction model differentiating AECOPD from stable state.
results28 patients (61% male) with a mean (SD) age of 65 (10.2) years with severe AECOPD were included. Metabolic alterations were predominantly detected in aminosugar, linoleate, and butanoate pathways. AECOPD could be discriminated from stable state with high power (AUC = 0.84), and balanced good sensitivity and specificity (86% each).
conclusionMetabolic analysis of AECOPD revealed disturbances in aminosugar metabolism as a potential driver mechanism and thus may be a therapeutic target for patients with exacerbations despite triple inhaled therapy. Moreover, real-time breath analysis could enable rapid detection of AECOPD, improving diagnostic accuracy and treatment efficiency.
trial registrationClinicalTrials.gov (NCT04638920), registered on 20.11.2020.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.