ArticleBMC medical imaging2025
Automated deep learning method for whole-breast segmentation in contrast-free quantitative MRI.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo develop a deep learning segmentation method utilizing the nnU-Net architecture for fully automated whole-breast segmentation based on diffusion-weighted imaging (DWI) and synthetic MRI (SyMRI) images.
methodsA total of 98 patients with 196 breasts were evaluated. All patients underwent 3.0T magnetic resonance (MR) examinations, which incorporated DWI and SyMRI techniques. The ground truth for breast segmentation was established through a manual, slice-by-slice approach performed by two experienced radiologists. The U-Net and nnU-Net deep learning algorithms were employed to segment the whole-breast. Performance was evaluated using various metrics, including the Dice Similarity Coefficient (DSC), accuracy, and Pearson's correlation coefficient.
resultsFor DWI and proton density (PD) of SyMRI, the nnU-Net outperformed the U-Net achieving the higher DSC in both the testing set (DWI, 0.930 ± 0.029 vs. 0.785 ± 0.161; PD, 0.969 ± 0.010 vs. 0.936 ± 0.018) and independent testing set (DWI, 0.953 ± 0.019 vs. 0.789 ± 0.148; PD, 0.976 ± 0.008 vs. 0.939 ± 0.018). The PD of SyMRI exhibited better performance than DWI, attaining the highest DSC and accuracy. The correlation coefficients R² for nnU-Net were 0.99 ~ 1.00 for DWI and PD, significantly surpassing the performance of U-Net.
conclusionThe nnU-Net exhibited exceptional segmentation performance for fully automated breast segmentation of contrast-free quantitative images. This method serves as an effective tool for processing large-scale clinical datasets and represents a significant advancement toward computer-aided quantitative analysis of breast DWI and SyMRI images.
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