ArticleBMC infectious diseases2025
A pilot study evaluating mid-point vancomycin concentrations to estimate pharmacokinetics and area under the curve: a prospective study.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundGuidelines recommend monitoring vancomycin by estimating the area under the curve (AUC
methodsA prospective study that included critically ill cancer patients with stable kidney function who received vancomycin during their ICU stay. Trough, peak, and midpoint concentrations were measured at steady-state. Pharmacokinetic equations from the short infusion model was used to calculate the AUC
resultsWe included 91 patients, with a mean age of 53 years ± 17 (SD), 54% were males, and 77% had solid tumors. The mean prescribed vancomycin dose was 15 mg/kg/dose ± 3 (SD). Median AUC
conclusionsUtilization of mid-point vancomycin levels to calculate pharmacokinetic parameters demonstrated promising findings. Further research with larger and more diverse patient populations is needed to evaluate this approach further.
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