ArticleBMC gastroenterology2025
Lactate-to-albumin ratio as an independent predictor of mortality in critically ill patients with gastrointestinal bleeding: a retrospective cohort study.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Lactate to albumin ratio LAR predicts mortality in critically ill adults with asthma across two cohorts.Scientific reports · 2026Article
- Lactate-to-albumin ratio as an independent predictor of short- and long-term mortality in ICU patients with malignant tumors: A retrospective cohort study.Oncology letters · 2026Article
- Association of Early Postoperative Biochemical Markers with a Composite Adverse Perioperative Outcome After Bariatric Surgery.Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe lactate-to-albumin ratio (LAR) is an established prognostic marker in various critical illnesses; However, its association with gastrointestinal bleeding (GIB) in patients has not been thoroughly investigated. This study evaluates the prognostic role of LAR in critically ill patients with GIB.
methodsData were extracted from the publicly available MIMIC-IV database (v3.1). We assessed the prognostic value of the LAR for both short- and long-term mortality using multivariable Cox proportional hazards regression. Survival differences were analyzed using Kaplan-Meier (K-M) curves with log-rank tests. Discrimination ability was evaluated using receiver operating characteristic (ROC) curve analysis, while nonlinear associations were examined using restricted cubic splines (RCS). Subgroup analyses were conducted to test for potential effect modification. Finally, a Boruta algorithm-based nomogram was developed to integrate key predictors.
resultThis retrospective cohort study enrolled 1,210 critically ill patients with gastrointestinal bleeding, demonstrating an ICU mortality rate of 21.7%. Using X-tile analysis, we stratified patients into tertiles (Q1-Q3) based on LAR and 28-day mortality. Multivariable Cox regression confirmed LAR as an independent predictor of mortality (P < 0.001), with K-M analysis revealing significantly worse survival in higher LAR groups (P < 0.001). ROC analysis showed moderate predictive accuracy, while integrating LAR with SOFA score enhanced performance compared to either parameter alone. Decision curve analysis (DCA) demonstrated clinical utility, and RCS regression indicated a linear dose-response relationship between LAR and mortality risk. Subgroup analyses revealed no significant effect modification. A Boruta-optimized nomogram incorporating LAR achieved robust predictive performance for 28-day (AUC 0.780, 95% CI 0.750-0.811), 90-day (0.777, 0.749-0.805), and 365-day mortality (0.773, 0.745-0.800).
conclusionThe LAR independently predicts short- and long-term mortality in critically ill gastrointestinal bleeding patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.