Evidence map›Paper›PMID 41013304›Full record

SynthesisBMC infectious diseases2025

Burden of malaria infection among most vulnerable populations in Ethiopia: an umbrella review of systematic reviews and meta-analyses.

Ababo Demeke, Getu Kassa, Habtamu Gebrie, Samuel Tefera, Eyob Getu, Samuel Jigso Dube, Alem Bayable, Adamu Kassie, Birhanu Muleta, Wondimagene Wolde Eba and 2 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ababo DemekeDepartment of Nursing, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia.
Getu KassaSchool of Public Health, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia.
Habtamu GebrieDepartment of Medical Laboratory Science, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia.
Samuel TeferaDepartment of Medical Laboratory Science, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia.
Eyob GetuDepartment of Medical Laboratory Science, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia.
Samuel Jigso DubeDepartment of Nursing, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia.
Alem BayableDepartment of Nursing, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia.
Adamu KassieDepartment of Medical Laboratory Science, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia.
Birhanu MuletaDepartment of Nursing, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia.
Wondimagene Wolde EbaDepartment of Medical Laboratory Science, College of Health Science, Oda Bultum University, Chiro, Ethiopia.
Behailu Taye GebremeskeleDepartment of Medical Laboratory Science, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia.
Abel Desalegn DemekeDepartment of Nursing, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia. adesalegn2513@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria is a protozoan disease caused by species of plasmodium. Despite the expanded control efforts, it continues to threaten vulnerable groups in Ethiopia. It remains a leading cause of illness and death, particularly among pregnant women, children, and migrant populations. Though previous studies report varying estimates of prevalence and risk factors, findings remain inconsistent. This umbrella review synthesizes existing systematic reviews and meta-analyses studies to clarify the burden and key predictors of malaria, offering consolidated evidence to guide targeted interventions.

methodsThis umbrella review included six systematic reviews and meta-analyses identified through comprehensive searches of PubMed, Hinari, Science Direct, and Google Scholar. Eligible studies were published in English up to June 20, 2025, and focused on malaria prevalence or risk factors among children, pregnant women, or migrant populations in Ethiopia. The quality of included studies was assessed using Measurement Tool to Assess Systematic Reviews version 2 checklists. For analyses, a random-effects model was used. STATA software version 17 was used to conduct the analyses.

resultFrom 3388 total records, six systematic reviews and meta-analyses were included. The overall pooled prevalence of malaria among vulnerable populations was 10.10% (95% CI: 0.36–19.85), with low heterogeneity (I² = 0.0%, P = 0.982). Not utilizing insecticide-treated mosquito net (pooled odds ratio: 5.22, 95% CI: 3.93–6.94) and proximity to stagnant water (pooled odds ratio: 4.21, 95% CI: 2.75–6.46) were independently associated with increased malaria risk.

conclusionThis umbrella review highlights a considerable burden of malaria among the most vulnerable populations in Ethiopia, not utilizing insecticide-treated net and exposure to stagnant water emerging as consistent risk factors. By consolidating fragmented evidence from prior reviews, these findings offer clear guidance for targeted, evidence-based malaria prevention and control strategies. PROSPERO REGISTRATION NUMBER: CRD420251083494.

Indexed as

MalariaVulnerable PopulationsChildEthiopiaFemaleHumansMeta-Analysis as TopicPregnancyPrevalenceRisk FactorsSystematic Reviews as TopicEthiopiaMalariaUmbrella reviewVulnerable populations

Identifiers

PMID41013304
PMCPMC12465557

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.