Evidence map›Paper›PMID 41013298›Full record

Observational studyBMC nephrology2025

Thrombotic microangiopathy multidisciplinary assessment team: demographics, final diagnosis, treatment, and outcomes.

Matthew Nguyen, Gayathri Dileep, Samir Patel, Fawaz Al Ammary, Minh-Ha Tran, Benjamin J Lee, Stefan Ciurea, Sheetal Desai, Alpesh Amin, Hongyu Zhao and 16 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Matthew NguyenDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Gayathri DileepDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Samir PatelDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Fawaz Al AmmaryDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Minh-Ha TranDepartment of Medicine, Division of Transfusion Medicine, University of California Irvine, Irvine, CA, USA.
Benjamin J LeeDepartment of Medicine, Division of Hematology Oncology, University of California Irvine, Irvine, CA, USA.
Stefan CiureaDepartment of Medicine, Division of Hematology Oncology, University of California Irvine, Irvine, CA, USA.
Sheetal DesaiDepartment of Medicine, Division of Rheumatology, University of California Irvine, Irvine, CA, USA.
Alpesh AminDepartment of Medicine, University of California Irvine, Irvine, CA, USA.
Hongyu ZhaoDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Omid VadpeyDepartment of Medicine, University of California Irvine, Irvine, CA, USA.
Dao LeDepartment of Medicine, University of California Irvine, Irvine, CA, USA.
Tai TruongDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Antoinette AbdelmalekDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Jordan PerkinsDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Rebecca AhdootDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Fatima MalikDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Antoney FerreyDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Uttam ReddyDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Ekamol TantisattamoDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Yongen ChangDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Wei Ling LauDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Yulian KhagiDepartment of Medicine, Division of Nephrology, University of California Irvine - VA LBMC, Irvine, CA, USA.
Lisa LeeDepartment of Medicine, Division of Hematology Oncology, University of California Irvine, Irvine, CA, USA.
Zahra PakbazDepartment of Medicine, Division of Hematology Oncology, University of California Irvine, Irvine, CA, USA.
Ramy M HannaDepartment of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA. Ramyh1@hs.uci.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RATIONALE &

objectiveThrombotic Microangiopathies (TMAs) include an etiological diverse group of phenotypically similar disorders. While individually rare, they are seen as an aggregate with regularity. Prior reports suggested the importance of approaching TMAs in a multidisciplinary fashion. We present the development and data over a 4-year period after establishing the University of California Irvine (UCI) TMA team. DESIGN, SETTINGS, PARTICIPANTS, AND MEASUREMENTS: This is a single-center retrospective case observational study of 101 diverse patients demonstrating demographics, diagnoses, triggers, treatments applied, and outcomes representing a wide range of hematologic pathologies.

findingsOf the 101 patients, 47 were females with an age range between 18 and 83 years old. 46 of our 101 patients were diagnosed with TMA. 24 patients were diagnosed with atypical hemolytic uremic syndrome (aHUS). Eight patients were diagnosed with Hematopoietic Stem Cell Transplant TMA (HSCT-TMA). Of the 24 aHUS patients, 16 were treated and 8 were evaluated for complement blockade. Of those treated, 100% demonstrated a hematologic response, 81.3% had initial renal remission and 68.8% of those who were on dialysis (11 of 16) remain off dialysis. Of the 8 HSCT-TMA patients, 5 were treated and 3 were evaluated for complement blockade. Of those treated, 80% demonstrated a hematologic response, 100% had initial renal remission; however, of all treated patients eventually returned to needing dialysis. LIMITATIONS AND

conclusionsThis observational study highlights the importance of the TMA multidisciplinary team to improve diagnosis and optimize outcomes of this rare condition. Future research is needed to subdivide response to various TMA to current and emerging therapies in the context of multidisciplinary care. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Patient Care TeamThrombotic MicroangiopathiesAdolescentAdultAgedAged, 80 and overAtypical Hemolytic Uremic SyndromeFemaleHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedRenal DialysisRetrospective StudiesTreatment OutcomeYoung AdultComplement-Mediated Thrombotic Microangiopathy (CM-TMA)GlomerulonephritisHematologyHematopoietic stem cell transplantMultidisciplinary teamNephrologyRare disorderThrombotic Microangiopathy (TMA)Thrombotic thrombocytopenic purpura

Identifiers

PMID41013298
PMCPMC12465760

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.