ArticleBMC geriatrics2025
Healthy aging: how does a multidimensional construct of functional ability predict objective and subjective outcomes?
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the comprehensive and holistic conceptual approach proposed by the WHO to measure Functional Ability (FA) in healthy aging, research exploring both intrinsic capacity (IC) and environments is rare. This study aimed to define a multidimensional FA construct based on the WHO framework and investigate its association with objective (mortality, IADL-disability) and subjective (poor life satisfaction, poor perceived health) outcomes.
methodsThe sample included 587 older participants from the AMI (Aging Multidisciplinary Investigation) epidemiological cohort. In total eight subdomains of FA were defined using Structural Equation Models: five related to IC and three to the living environment (from 30 collected variables in total). Cox regression models were used to investigate the association between FA and incident adverse outcomes.
resultsParticipants were classified into four levels of FA (34% in very high, 16% in high, 22% in medium, and 28% in low). Compared to those with very high FA, participants with low FA had significantly higher risks of death (Hazard Ratio HR = 2.19; 95% Confidence Interval: 1.30-3.68), IADL-disability (HR = 3.13; 95% CI: 1.99-4.92) and were more likely to experience poor life satisfaction (HR = 1.87; 95% CI: 1.15-3.03) and poor perceived health (HR = 3.97; 95% CI: 1.85-8.53).
conclusionLow FA levels are strongly associated with increased risks of both objective and subjective negative outcomes. These findings highlight the importance of simultaneously considering IC and environment to properly explore FA in healthy aging.
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