SynthesisBMC cardiovascular disorders2025
The prognostic role of right ventricular-pulmonary arterial coupling in aortic stenosis patients undergoing TAVR: a systematic review and meta-analysis.
Synthesis in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Right heart function matters: prognostic value of sPAP, TAPSE and RV-PA coupling in a real-world cohort of TAVI patients.Cardiovascular intervention and therapeutics · 2026Article
- Evolution of Cardiac Damage Across Clinically Defined Stages of Aortic Stenosis in Patients Undergoing TAVR: A Single-Center Retrospective Cohort Study.Journal of clinical medicine · 2026Article
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Abstract
backgroundThe predictive role of right ventricular-pulmonary arterial (RV-PA) uncoupling following transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis (AS) is inconsistent. Thus, this meta-analysis aimed to evaluate the prognostic value of RV-PA coupling in patients undergoing TAVR.
methodsWe systematically searched PubMed, Embase, and Web of Science databases for studies reporting the prognostic relevance of RV-PA coupling in patients undergoing TAVR. Fixed- or random-effects models were employed according to heterogeneity. Subgroup analyses were conducted to evaluate the influence of study characteristics on the analyzed results.
resultsEighteen studies involving 5,905 patients were included. The pooled results demonstrated that RV-PA uncoupling prior to TAVR was associated with the increased all-cause mortality risk, with a hazard ratio (HR) of 2.36 (95% CI: 1.76–3.16) in univariate analysis and an adjusted hazard ratio (aHR) of 2.01 (95% CI: 1.40–2.89) in multivariate analysis. Moreover, both non-severe RV-PA (HR = 1.71, 95% CI: 1.02–2.86) and severe RV-PA uncoupling (HR = 2.73, 95% CI: 1.50–4.95) were associated with elevated mortality risk in univariate analysis. Multivariate analysis showed increased all-cause mortality risk in patients with non-severe/severe uncoupling, but these findings were not statistically significant.
conclusionRV-PA uncoupling was identified as a predictor of adverse outcomes after TAVR. Incorporating assessment of RV-PA coupling may enhance risk stratification and prognostic prediction in the TAVR patient population.
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