Evidence map›Paper›PMID 41013184›Full record

ArticleBMC genomics2025

Prenatal nicotine exposure induces epigenetic alterations in the Notch signaling genes in the proximal colon in rats.

Ouzna Dali, Celine Heitz-Marchaland, Pierre-Yves Kernanec, Javier Carrion-Padilla, Baptiste Godin, Sergei Tevosian, Jasenka Zubcevic, Linda F Hayward, Fatima Smagulova

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Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ouzna Dali *Univ. Rennes, EHESP, InsermIrset (Institut de Recherche en Santé, environnement et travail) - UMR_S 1085, Rennes, 35000, France.
Celine Heitz-Marchaland *Univ. Rennes, EHESP, InsermIrset (Institut de Recherche en Santé, environnement et travail) - UMR_S 1085, Rennes, 35000, France.
Pierre-Yves KernanecUniv. Rennes, EHESP, InsermIrset (Institut de Recherche en Santé, environnement et travail) - UMR_S 1085, Rennes, 35000, France.
Javier Carrion-PadillaUniv. Rennes, EHESP, InsermIrset (Institut de Recherche en Santé, environnement et travail) - UMR_S 1085, Rennes, 35000, France.
Baptiste GodinUniv. Rennes, EHESP, InsermIrset (Institut de Recherche en Santé, environnement et travail) - UMR_S 1085, Rennes, 35000, France.
Sergei TevosianDepartment of Physiological Sciences, University of Florida, 1333 Center Drive, Box 100144, Gainesville, FL, 32610, USA.
Jasenka ZubcevicDepartment of Physiology and Pharmacology, University of Toledo, Toledo, OH, USA.
Linda F HaywardDepartment of Physiological Sciences, University of Florida, 1333 Center Drive, Box 100144, Gainesville, FL, 32610, USA.
Fatima SmagulovaUniv. Rennes, EHESP, InsermIrset (Institut de Recherche en Santé, environnement et travail) - UMR_S 1085, Rennes, 35000, France. fatima.smagulova@inserm.fr.

Funding

Florida Department of Health James and Esther King Biomedical Research Program 8JK06
6 · The paper itself

Abstract

backgroundPrenatal nicotine exposure (PNE) has been shown to significantly impact fetal development, leading to various pathologies in adulthood.

objectivesIn this study, we analyzed the epigenetic effects of PNE on the proximal colon.

resultsWe show here that PNE decreases the length of the colon crypts and induces a higher Ki-67 index. The genes related to metabolic pathways, tight junctions, and neurodegenerative processes were downregulated in PNE colons, and genes related to inflammation and oxygen transporter activity were upregulated. We observed a decrease in acetylated H4Ac and H3K9Ac marks. Genome-wide DNA methylation analysis demonstrated reduced DNA methylation of genes related to cell adhesion and metabolic pathways and increased methylation levels at thermogenesis, GABAergic synapsing, and non-alcoholic fatty liver disease-related genes. The Notch signaling pathway was deregulated in PNE rats.

conclusionPNE leads to perturbation of proximal colon functioning, plausibly through nicotine-induced epigenetic alterations.

Indexed as

ColonEpigenesis, GeneticNicotinePrenatal Exposure Delayed EffectsReceptors, NotchSignal TransductionAnimalsDNA MethylationFemaleMalePregnancyRatsNicotineReceptors, NotchDNA methylationHistone acetylation marksNicotineNotch signalingProximal colonRNA-seq

Identifiers

PMID41013184
PMCPMC12466058

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.