Evidence map›Paper›PMID 41013180›Full record

ArticleMolecular medicine (Cambridge, Mass.)2025

Immunogenicity and memory B-cell potency induced by an inactivated COVID-19 vaccine in pregnant women.

Gui-Ping Wen, Yi-Zhen Wang, Min-Ming Wang, Wen-Rong Wang, Si-Ling Wang, Zheng Wang, Zi-Min Tang, Zhen-Yu Luo, Zi-Hao Chen, Jia-Yan Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gui-Ping Wen *Department of Central Laboratory, Fujian Key Clinical Specialty of Laboratory Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China. wenguiping@xmu.edu.cn.
Yi-Zhen Wang *State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
Min-Ming Wang *United Diagnostic and Research Center for Clinical Genetics, Women and Children's Hospital, School of Medicine, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
Wen-Rong Wang *Department of Aristogenesis, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China.
Si-Ling Wang *State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
Zheng WangUnited Diagnostic and Research Center for Clinical Genetics, Women and Children's Hospital, School of Medicine, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
Zi-Min TangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
Zhen-Yu LuoDepartment of Aristogenesis, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China.
Zi-Hao ChenState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
Jia-Yan ChenDepartment of Central Laboratory, Fujian Key Clinical Specialty of Laboratory Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China.
Mei-Jiao CaiDepartment of Central Laboratory, Fujian Key Clinical Specialty of Laboratory Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China.
Yun-Sheng GeDepartment of Central Laboratory, Fujian Key Clinical Specialty of Laboratory Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China.
Zi-Zheng ZhengState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China. zhengzizheng@xmu.edu.cn.
Yu-Lin ZhouDepartment of Central Laboratory, Fujian Key Clinical Specialty of Laboratory Medicine, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China. zhou_yulin@126.com.

Funding

Fujian Provincial Natural Science Foundation of China 2022J02005Fujian Provincial Natural Science Foundation of China 2023J011607Fujian Provincial Natural Science Foundation of China 2023J05263National Key Research and Development Program of China 2024YFC2310602National Natural Science Foundation of China 82101757Science and Technology Project of Xiamen 3502Z20224014the Xiamen Health High Quality Development Science and Technology Project 2024GZL-GG39
6 · The paper itself

Abstract

During pregnancy, profound immunological, hormonal, and metabolic adaptations occur to support fetal development. The impact of pregnancy on vaccine-induced immunity remains incompletely characterized, as previous studies have primarily focused on serological antibody levels but not immune memory. Immune memory is critical for vaccine effectiveness, but effect of pregnancy on immune memory remain unknown. In addition, the memory B cell response profile induced by inactivated coronavirus disease 2019 (COVID-19) vaccines in pregnant women remains unclear. This study comprehensively investigated the serological responses and memory B cell response induced by an inactivated COVID-19 vaccine in pregnant women. The results demonstrated that while pregnant women and non-pregnant women of childbearing age showed comparable serological antibody levels, vaccine-induced monoclonal antibodies (mAbs) from pregnant women exhibited significantly lower binding potency to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and its segments and weaker neutralizing potency and breadth than those from non-pregnant women. Vaccine-induced mAbs from pregnant women were derived predominantly from IGHV3-30, whereas those from non-pregnant women were derived diverse germline genes. Most of mAbs from pregnant women targeted the receptor-binding domain (RBD) (40.9%) and S2 domain (31.8%), whereas most of mAbs from non-pregnant women targeted the RBD (51.3%) and N-terminal domain (30.8%). These findings suggested that pregnancy may impair the potency of vaccine-induced memory B cells. These insights may be valuable for the development of vaccination strategies for pregnant women.

Indexed as

B-LymphocytesCOVID-19COVID-19 VaccinesImmunogenicity, VaccineMemory B CellsSARS-CoV-2AdultAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralFemaleHumansImmunologic MemoryPregnancySpike Glycoprotein, CoronavirusVaccines, InactivatedAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Vaccines, InactivatedHumoral immune responseInactivated COVID-19 vaccineMemory B cellPregnancySARS-CoV-2.

Identifiers

PMID41013180
PMCPMC12465604

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.