Evidence map›Paper›PMID 41012825›Full record

ArticleVeterinary sciences2025

Comparative Study of DTMUV and LPS on Duck Liver Disease.

Zhenghui Lan, Zhigang Sun, Yi Wang, Huatao Li, Xuejing Sun

Abstract read
In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhenghui LanCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.
Zhigang SunCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.
Yi WangCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.
Huatao LiCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.
Xuejing SunCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.

Funding

Qingdao Agricultural University Research Fund for High-level Talents 633/1120020Youth Innovation Team Project of Shandong Province Higher Educational Science and Technology Program 2021KJ102
6 · The paper itself

Abstract

This study investigated the structural features of adult duck liver and compared pathological alterations induced by duck Tembusu virus (DTMUV, strain XZ-2012) and lipopolysaccharide (LPS). Histological techniques (HE, reticular fiber, and trichrome staining) revealed normal duck liver exhibited reddish-brown coloration with indistinct lobule boundaries and no prominent bile ducts. Kupffer cell distribution was mapped via jugular ink injection. DTMUV infection caused liver swelling, congestion, and yellowish discoloration. Histopathology showed lymphocyte infiltration around central veins and portal areas, increased reticular fibers, thickened basement membranes, hepatocyte vacuolation, and erythrocyte accumulation in sinusoids. In contrast, LPS exposure led to mild hepatic enlargement without vacuolar degeneration but with marked perivascular lymphocyte aggregation and reticular fiber proliferation. Both treatments elevated Kupffer cell numbers. These findings demonstrate distinct liver injury patterns: DTMUV induces direct hepatocellular damage with inflammatory responses, while LPS triggers intense immune cell recruitment without significant hepatocyte degeneration. The study provides insights into avian viral versus bacterial pathogenesis and liver defense mechanisms, offering a foundation for further research into waterfowl infectious diseases.

Indexed as

comparative histopathologyduckduck tembusu viruslipopolysaccharideliver

Identifiers

PMID41012825
PMCPMC12474332

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.