Evidence map›Paper›PMID 41012789›Full record

ArticleVeterinary sciences2025

Antiviral Activity of Diltiazem HCl Against Pseudorabies Virus Infection In Vitro.

Mengting Zuo, Decai Xiang, Zhen-Xing Zhang, Xi Yang, Yuqing Duan, Juan Li, Bangquan Zeng, Lu Dong, Guoquan Wu, Yi Zhou and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mengting ZuoHunan Provincial Key Laboratory of the TCM Agricultural Biogenomics, Changsha Medical University, Changsha 410219, China.
Decai XiangYunnan Tropical and Subtropical Animal Virus Diseases Laboratory, Yunnan Animal Science and Veterinary Institute, Kunming 650224, China.
Zhen-Xing ZhangYunnan Tropical and Subtropical Animal Virus Diseases Laboratory, Yunnan Animal Science and Veterinary Institute, Kunming 650224, China.
Xi YangCollege of Animal Science and Technology, Yangtze University, Jingzhou 434025, China.
Yuqing DuanCollege of Animal Science and Technology, Yangtze University, Jingzhou 434025, China.
Juan LiYunnan Sino-Science Gene Technology Co., Ltd., Kunming 650501, China.
Bangquan ZengCentral for Animal Disease Control and Prevention of Yunnan Province, Kunming 650201, China.
Lu DongCentral for Animal Disease Control and Prevention of Yunnan Province, Kunming 650201, China.
Guoquan WuYunnan Tropical and Subtropical Animal Virus Diseases Laboratory, Yunnan Animal Science and Veterinary Institute, Kunming 650224, China.ORCID 0000-0002-3747-1565
Yi ZhouHunan Provincial Key Laboratory of the TCM Agricultural Biogenomics, Changsha Medical University, Changsha 410219, China.
Lei TanCollege of Animal Science and Technology, Yangtze University, Jingzhou 434025, China.
Bofang DuanCentral for Animal Disease Control and Prevention of Yunnan Province, Kunming 650201, China.

Funding

Innovation Guidance and Technology oriented Enterprise Cultivation Plan Project Yunnan Province 202404BI090004the Science and Technology Research Project of Education Department of Hubei Province Q20231308the Scientific Research Foundation of Hunan Provincial Education Department 23B0871
6 · The paper itself

Abstract

Pseudorabies virus (PRV) is a highly pathogenic agent that adversely impacts swine populations, leading to considerable economic losses within the Chinese pig industry. Furthermore, the potential for PRV to transmit across species from pigs to other hosts has attracted significant attention. In light of this, it is essential to identify efficacious antiviral agents for the treatment of PRV infection. In this study, we investigated the antiviral properties of Diltiazem HCl (DTZ) against PRV infection in susceptible cell lines. Our results demonstrated that DTZ significantly inhibited PRV infection in both PK15 and Vero cells. Moreover, this chemical compound exhibited antiviral activity against both variant and classical strains of PRV, as well as herpes simplex virus type 1 (HSV-1). Time-of-addition assays showed that DTZ exerted its inhibitory effect through specific interference with the virus replication process. Subsequent transcriptomic analysis via RNA sequencing indicated that the calcium signaling pathway might be involved in the antiviral properties of DTZ against PRV infection. Specifically, treatment with EGTA or calcium ion (Ca

Indexed as

antiviral activitydiltiazem HClpseudorabies virusRNA-seqviral replication phase

Identifiers

PMID41012789
PMCPMC12474134

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.