Evidence map›Paper›PMID 41012713›Full record

ArticleVeterinary sciences2025

Hepatocellular Early Apoptosis Associated with HES 130/0.4 Administration for Volume Replacement in Pigs After Severe Bleeding.

Helena Vala, Ana I Faustino-Rocha, Rita Cruz, Carlos Venâncio, Aura Silva, João R Mesquita, Ana Liza Ortiz, David A Ferreira

Abstract read
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In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Helena ValaResearch Center for Natural Resources, Environment and Society (CERNAS), Polytechnic Institute of Viseu, 3504-510 Viseu, Portugal.ORCID 0000-0001-6829-4867
Ana I Faustino-RochaCentre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, 5000-801 Vila Real, Portugal.ORCID 0000-0001-5572-6317
Rita CruzEpidemiology Research Unit (EPIUnit), Institute of Public Health, University of Porto, 4050-313 Porto, Portugal.
Carlos VenâncioCentre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, 5000-801 Vila Real, Portugal.ORCID 0000-0003-3880-3442
Aura SilvaPortuguese Research Centre for Sustainable Chemistry (REQUIMTE), Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-2044-6320
João R MesquitaAgrarian School of Viseu (ESAV), Polytechnic Institute of Viseu, 3504-510 Viseu, Portugal.ORCID 0000-0001-8769-8103
Ana Liza OrtizDepartment of Veterinary Medicine, University of Cambridge, Cambridge CB2 ITN, UK.ORCID 0000-0001-6317-9237
David A FerreiraUniversity of Évora, Comprehensive Health Research Center (CHRC), 7004-516 Évora, Portugal.ORCID 0000-0002-9720-3140

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydroxyethyl starch (HES) 130/0.4 is commonly used for volume replacement, yet its hepatic effects in the context of acute haemorrhage remain unclear. This study aimed to evaluate hepatic histopathological changes related to HES 130/0.4 administration when compared to Ringer's lactate (RL) in healthy pigs subjected to acute bleeding under general anaesthesia. Eighteen pigs were randomised into three groups: RL (

Indexed as

apoptosishemorrhageHES 130/0.4histopathologyliver

Identifiers

PMID41012713
PMCPMC12474367

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.