Evidence map›Paper›PMID 41012709›Full record

ArticleViruses2025

Cervical Secretions from Women After Depot Medroxyprogesterone Acetate (Depo-Provera) Administration Promote HIV Infectivity Ex Vivo.

Carley Tasker, Natalie E Roche, Yungtai Lo, Theresa L Chang

Abstract read
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carley TaskerPublic Health Research Institute, Rutgers, New Jersey Medical School, 225 Warren Street, Newark, NJ 07103, USA.
Natalie E RocheDepartment of Obstetrics, Gynecology & Women's Health, Rutgers, New Jersey Medical School, Newark, NJ 07103, USA.
Yungtai LoDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0002-2694-4830
Theresa L ChangPublic Health Research Institute, Rutgers, New Jersey Medical School, 225 Warren Street, Newark, NJ 07103, USA.ORCID 0000-0003-0696-9755

Funding

Einstein-Montefiore Clinical and Translational Science Award HubUM1TR004400 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Jessica Kahn, Mimi Y Kim · 2023 to 2026
$17.3M
Modulation of innate immunity,microbiome and HIV transmission by Depo-ProveraR01AI110372 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI CHANG, THERESA L, YANG, LIYING · 2013 to 2017
$3.0M
NCATS NIH HHS UM1 TR004400NIAID NIH HHS R01 AI110372NIH HHS 1R01AI117203-13
6 · The paper itself

Abstract

Depot medroxyprogesterone acetate (Depo-Provera) has been associated with an increased risk of HIV acquisition. We have previously shown that Depo-Provera administration increases immune markers for HIV preference on peripheral and cervical CD4

Indexed as

Cervix UteriContraceptive Agents, FemaleHIV-1HIV InfectionsMedroxyprogesterone AcetateAdultFemaleHumansVaginaYoung AdultContraceptive Agents, FemaleMedroxyprogesterone AcetateDepo-ProveraHIV infectivityvaginal and cervical mucosa

Identifiers

PMID41012709
PMCPMC12474013

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.