Evidence map›Paper›PMID 41012692›Full record

ArticleViruses2025

Prevalence and Genetic Diversity of Torque teno felis virus (FcTTV) in Domestic Cats from Kazakhstan.

Gulzhan Yessembekova, Bolat Abdigulov, Alexandr Shevtsov, Asylulan Amirgazin, Sarsenbay Abdrakhmanov, Elena Shevtsova, Symbat Bolysbekkyzy, Salima Baduanova, Alexandr Shustov

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Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Gulzhan YessembekovaFaculty of Veterinary and Animal Husbandry Technology, S. Seifullin Kazakh Agrotechnical University, Astana 010000, Kazakhstan.ORCID 0000-0001-6177-7612
Bolat AbdigulovNational Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0009-0004-4550-252X
Alexandr ShevtsovNational Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0000-0002-0307-1053
Asylulan AmirgazinNational Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0000-0001-9418-7758
Sarsenbay AbdrakhmanovFaculty of Veterinary and Animal Husbandry Technology, S. Seifullin Kazakh Agrotechnical University, Astana 010000, Kazakhstan.ORCID 0000-0003-3707-3767
Elena ShevtsovaNational Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0000-0002-7221-5866
Symbat BolysbekkyzyFaculty of Veterinary and Animal Husbandry Technology, S. Seifullin Kazakh Agrotechnical University, Astana 010000, Kazakhstan.
Salima BaduanovaNational Center for Biotechnology, Astana 010000, Kazakhstan.
Alexandr ShustovNational Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0000-0001-9880-9382

Funding

Ministry of Science and Higher Education of the Republic of Kazakhstan AP19679977
6 · The paper itself

Abstract

Anelloviruses have a broad mammalian host range, including Torque teno felis virus (FcTTV), a felid-associated member that remains undercharacterized. This is the first comprehensive study of FcTTV in domestic cats in Central Asia. We analyzed blood samples from 206 domestic cats from the large city of Astana, Kazakhstan, collected in 2023-2024. Using nested PCR we identified 63 FcTTV-positive samples (30.6% prevalence), and the sequences were compared to global reference strains. Potential demographic associations (sex and age) were assessed. The study revealed an overall FcTTV prevalence of 30.6%. Infection rates showed no significant sex-related differences: ages varied 4-168 months. ORF1 sequencing revealed multiple FcTTV variants in 27% of samples, with no demographic links. Phylogenetic analysis revealed distinct patterns at both nucleotide and amino acid levels: 3 groups of nucleotide sequences (max divergence 21.68%; intra-cluster 5.15-6.8%), and 3 clusters of amino acid sequences (max divergence 16.81%; intra-cluster 2.82-6.68%). Deletions were found in ORF1 in some variants. Global phylogeny aligned clusters with Asian/European strains (90-98% identity), confirming FcTTV1 affiliation and inter-regional transmission. Our study of FcTTV in Kazakhstan reveals moderate virus prevalence with considerable genetic diversity across viral strains and frequent co-infections with multiple variants.

Indexed as

Cat DiseasesDNA Virus InfectionsGenetic VariationTorque teno virusAnimalsCatsFemaleKazakhstanMalePhylogenyPrevalenceAnelloviridaedomestic catsgenetic diversityphylogenetic analysisTorque teno felis virus (FcTTV)

Identifiers

PMID41012692
PMCPMC12474289

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.