Evidence map›Paper›PMID 41012651›Full record

ArticleViruses2025

The Role of HBx Mutations in Chronic Hepatitis B with Acute Exacerbation.

Xiaobei Chen, Jinzhi Shi, Ping Zhou, Yunyun Tian, Yajing Zheng, Tingting Liu, Yan Li, Fan Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaobei ChenDepartment of Infectious Diseases, East Campus, Renmin Hospital of Wuhan University, Wuhan 430223, China.
Jinzhi ShiDepartment of Infectious Diseases, East Campus, Renmin Hospital of Wuhan University, Wuhan 430223, China.
Ping ZhouState Key Laboratory of Virology and Biosafety, Department of Medical Microbiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.ORCID 0009-0000-0545-0439
Yunyun TianDepartment of Infectious Diseases, East Campus, Renmin Hospital of Wuhan University, Wuhan 430223, China.
Yajing ZhengDepartment of Fever Clinic, East Campus, Renmin Hospital of Wuhan University, Wuhan 430223, China.
Tingting LiuDepartment of Fever Clinic, East Campus, Renmin Hospital of Wuhan University, Wuhan 430223, China.
Yan LiDepartment of Fever Clinic, East Campus, Renmin Hospital of Wuhan University, Wuhan 430223, China.ORCID 0009-0004-7378-443X
Fan ZhuState Key Laboratory of Virology and Biosafety, Department of Medical Microbiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.ORCID 0000-0001-7031-2956

Funding

National Natural Science Foundation of China No. 82272321
6 · The paper itself

Abstract

Hepatitis B virus (HBV) infection remains a significant global health burden, primarily due to its chronic complications, including acute exacerbation, cirrhosis, hepatocellular carcinoma (HCC), and related sequelae. Acute exacerbation of chronic hepatitis B (CHB-AE) is common and often represents the earliest clinical manifestation. The Hepatitis B virus X protein (HBx) (17-kDa) is not only essential for viral replication but also plays a role in the development of HCC. To investigate the role of HBx mutation in CHB-AE progression, we enrolled 33 hospitalized CHB-AE patients and 31 patients with HBV-related liver failure (controls) from mainland China between January 2017 and June 2018. Single mutation 36 of HBx was significantly more prevalent in CHB-AE patients (

Indexed as

Hepatitis B, ChronicHepatitis B virusMutationTrans-ActivatorsViral Regulatory and Accessory ProteinsAdultAgedCarcinoma, HepatocellularChinaDisease ProgressionDNA, ViralFemaleHumansMaleMiddle AgedVirus ReplicationDNA, Viralhepatitis B virus X proteinTrans-ActivatorsViral Regulatory and Accessory Proteinsacute exacerbationchronic hepatitis BHBV-related liver failuremutationX protein

Identifiers

PMID41012651
PMCPMC12474432

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.