Evidence map›Paper›PMID 41012613›Full record

ArticleViruses2025

Development and Clinical Validation of a Skin Test for In Vivo Assessment of SARS-CoV-2 Specific T-Cell Immunity.

Tikhon V Savin, Vladimir V Kopat, Elena D Danilenko, Alexey A Churin, Anzhelika M Milichkina, Edward S Ramsay, Ilya V Dukhovlinov, Andrey S Simbirtsev, Areg A Totolian

Abstract readValidation Study
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tikhon V SavinSaint Petersburg Pasteur Institute, Mira St. 14, 197101 St. Petersburg, Russia.ORCID 0000-0003-4550-4870
Vladimir V KopatLLC "ATG Service Gene", Maly Prospekt of Vasilievsky Island 57, Building 4, 199178 St. Petersburg, Russia.ORCID 0000-0002-6573-6743
Elena D DanilenkoInstitute of Medical Biotechnology, State Research Centre of Virology and Biotechnology "Vector", Khimzavodskaya St. 9, 633009 Berdsk, Novosibirsk Region, Russia.
Alexey A ChurinGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Lenin Avenue 3, 634028 Tomsk, Russia.ORCID 0000-0002-6088-7286
Anzhelika M MilichkinaSaint Petersburg Pasteur Institute, Mira St. 14, 197101 St. Petersburg, Russia.
Edward S RamsaySaint Petersburg Pasteur Institute, Mira St. 14, 197101 St. Petersburg, Russia.ORCID 0000-0001-7086-5825
Ilya V DukhovlinovLLC "ATG Service Gene", Maly Prospekt of Vasilievsky Island 57, Building 4, 199178 St. Petersburg, Russia.
Andrey S SimbirtsevSaint Petersburg Pasteur Institute, Mira St. 14, 197101 St. Petersburg, Russia.
Areg A TotolianSaint Petersburg Pasteur Institute, Mira St. 14, 197101 St. Petersburg, Russia.ORCID 0000-0003-4571-8799

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel skin test for an in vivo assessment of SARS-CoV-2-specific T-cell immunity was developed using CoronaDermPS, a multiepitope recombinant polypeptide encompassing MHC II-binding CD4+ T-cell epitopes of the SARS-CoV-2 structural proteins (S, E, M) and full length nucleocapsid (N). In silico epitope prediction and modeling guided antigen design, which was expressed in

Indexed as

COVID-19SARS-CoV-2Skin TestsT-LymphocytesAdultAgedAnimalsCOVID-19 VaccinesEpitopes, T-LymphocyteFemaleHumansHypersensitivity, DelayedImmunity, CellularMacaca mulattaMaleMiceCOVID-19 VaccinesEpitopes, T-Lymphocytecell-mediated immunityCorD_PSCoronaDerm-PSDTHSARS-CoV-2skin test

Identifiers

PMID41012613
PMCPMC12474111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.