Evidence map›Paper›PMID 41012599›Full record

ArticleViruses2025

Human-Derived H3N2 Influenza A Viruses Detected in Pigs in Northern Italy.

Laura Soliani, Ada Mescoli, Irene Zanni, Laura Baioni, Giovanni Alborali, Ana Moreno, Silvia Faccini, Carlo Rosignoli, Giorgia De Lorenzi, Laura Fiorentini and 5 more

Abstract read
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Laura SolianiWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.ORCID 0000-0002-3497-1601
Ada MescoliWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.
Irene ZanniWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.
Laura BaioniWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.
Giovanni AlboraliWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.ORCID 0000-0002-4693-6395
Ana MorenoWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.ORCID 0000-0002-8497-9708
Silvia FacciniWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.ORCID 0000-0003-3411-958X
Carlo RosignoliWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.
Giorgia De LorenziWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.ORCID 0000-0003-2951-223X
Laura FiorentiniWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.ORCID 0000-0002-2730-2362
Camilla TorreggianiWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.ORCID 0000-0002-6525-4699
Benedetta CordioliWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.ORCID 0000-0003-3721-2915
Alice ProsperiWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.ORCID 0000-0002-1134-9764
Andrea LuppiWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.ORCID 0000-0002-1457-3518
Chiara ChiapponiWOAH Reference Laboratory for Swine Influenza, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.ORCID 0000-0001-8808-4680

Funding

EU funding within the NextGenerationEU-MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases Project no. PE00000007, INF-ACTItalian Ministry of Health "Ricerca Corrente" grant number IZS LER RC 2023006Italian Ministry of Health Ricerca Corrente" grant number PRC2020005 IZSLER 05/20
6 · The paper itself

Abstract

In recent years, the four main swine influenza A virus (IAV-S) subtypes circulating in swine in the EU have been H1avN1, H1huN2, H1N1pdm09, and H3N2. The latter emerged in 1984 from a reassortment event between a human seasonal H3N2 and H1avN1, and is currently detected at low prevalence in swine in Italy. Here, we describe nine H3N2 IAV-S isolates belonging to three novel genotypes, first detected in Italy in 2021, likely resulting from reassortment events between swine and human IAVs. The first genotype was characterized by a hemagglutinin (H3 HA) of human seasonal origin, a neuraminidase (N2 NA) derived from H1huN2 strains circulating in Italian swine, and an avian-like internal gene cassette (IGC). The second genotype differed in its IGC constellation: PB2, PB1, PA and NP segments were of pandemic origin (pdm09), while NS and M segments derived from the Eurasian avian-like lineage. The third genotype combined a human-derived H3, a Gent/84-derived N2, and a pdm09-origin IGC, except for an avian-like NS. This study aimed to characterize the genetic features of these novel H3huN2 and assess their epidemiological relevance, with implications for surveillance and control, improving preparedness and mitigating the risks posed by zoonotic influenza viruses.

Indexed as

Influenza A Virus, H3N2 SubtypeInfluenza, HumanOrthomyxoviridae InfectionsSwine DiseasesAnimalsGenotypeHemagglutinin Glycoproteins, Influenza VirusHumansItalyNeuraminidasePhylogenyReassortant VirusesSwineHemagglutinin Glycoproteins, Influenza VirusNeuraminidaseH3N2 virusesreassortant strainssurveillanceswine influenza viruses

Identifiers

PMID41012599
PMCPMC12474197

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.