Evidence map›Paper›PMID 41012591›Full record

ArticleViruses2025

The Impact of COVID-19 and Related Public Health Measures on Hepatitis C Testing in Ontario, Canada.

Yeva Sahakyan, Samantha S M Drover, Zoë R Greenwald, William W L Wong, Alexander Kopp, Richard L Morrow, Naveed Z Janjua, Beate Sander

Abstract read
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Gaps in the Hepatitis C Prenatal and Postpartum Care Cascade: Rationale for Treatment in Pregnancy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yeva SahakyanHealth Systems and Policy Research Collaborative Centre, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0002-7216-064X
Samantha S M DroverICES, Toronto, ON M4N 3M5, Canada.
Zoë R GreenwaldICES, Toronto, ON M4N 3M5, Canada.ORCID 0000-0001-7942-3951
William W L WongSchool of Pharmacy, University of Waterloo, Kitchener, ON N2G 1C5, Canada.
Alexander KoppICES, Toronto, ON M4N 3M5, Canada.
Richard L MorrowBritish Columbia Centre for Disease Control (BCCDC), Vancouver, BC V5Z 4R4, Canada.ORCID 0000-0002-5869-5197
Naveed Z JanjuaBritish Columbia Centre for Disease Control (BCCDC), Vancouver, BC V5Z 4R4, Canada.ORCID 0000-0001-5681-719X
Beate SanderHealth Systems and Policy Research Collaborative Centre, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0003-2128-9133

Funding

CIHR GR022612Tier 1 Canada Research Chair (CRC) in Economics of Infectious Diseases held by Beate Sander CRC-2022-00362
6 · The paper itself

Abstract

The COVID-19 pandemic disrupted progress towards global HCV elimination goals by interrupting essential health services in Canada and globally. We aimed to evaluate the effect of the pandemic on hepatitis C virus (HCV) testing rates in a population-based cohort study in Ontario using health administrative data. All residents with records of either HCV antibody or ribonucleic acid (RNA) tests were included. Monthly testing rate per 1000 population were compared during the pre-pandemic (01/01/2015-29/02/2020) and pandemic (01/03/2020-31/12/2022) periods using interrupted time series models, stratified by sex, homelessness, human immunodeficiency virus (HIV), and immigration status, and people who inject drugs (PWID). The HCV testing rate followed a statistically significant upward trend before the pandemic, dropping at its onset with 1.38/1000 fewer individuals initiating testing monthly. Compared to counterfactual estimates, the observed monthly number of people tested per 1000 population was lower by 1.41 (95% CI: 1.18-1.64) in 2020 (May-Dec), 1.17 (95% CI: 0.99-1.36) in 2021, and 1.41 (95% CI: 1.22-1.59) in 2022, corresponding to relative reductions of 47%, 34%, and 41%, respectively. Testing rates remained below expected levels across all subgroups throughout 2020-2022, with the greatest absolute declines observed among people co-infected with HIV, people experiencing homelessness, and PWID. Tailored, equity-focused interventions are needed to address these persistent gaps in HCV testing, without which Canada's progress toward its 2030 elimination targets remains at risk.

Indexed as

COVID-19Hepatitis CMass ScreeningPublic HealthAdultCohort StudiesFemaleHepacivirusHIV InfectionsHumansIll-Housed PersonsMaleMiddle AgedOntarioPandemicsSARS-CoV-2administrative dataCOVID-19hepatitis Cinterrupted time seriespopulation-based cohortpriority populations

Identifiers

PMID41012591
PMCPMC12474368

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.