Evidence map›Paper›PMID 41012585›Full record

ArticleViruses2025

Licoflavone B Suppresses Influenza A Virus by Targeting the Viral RNA-Dependent RNA Polymerase (RdRp).

Pu Fan, Peng Lv, Sen Zhang, Zheng Zhu, Kewen Qian, Jin Han, Yue Cui, Ye Feng, Zeya Li, Li Qiang and 5 more

Abstract read
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Viruses · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Pu FanSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Peng LvAcademy of Military Medical Sciences, Beijing 100071, China.ORCID 0000-0002-5719-7997
Sen ZhangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China.ORCID 0000-0003-1090-3193
Zheng ZhuAcademy of Military Medical Sciences, Beijing 100071, China.
Kewen QianAcademy of Military Medical Sciences, Beijing 100071, China.
Jin HanAcademy of Military Medical Sciences, Beijing 100071, China.
Yue CuiAcademy of Military Medical Sciences, Beijing 100071, China.
Ye FengState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China.
Zeya LiAcademy of Military Medical Sciences, Beijing 100071, China.
Li QiangAcademy of Military Medical Sciences, Beijing 100071, China.
Yunzhu DongAcademy of Military Medical Sciences, Beijing 100071, China.
Ting FangAcademy of Military Medical Sciences, Beijing 100071, China.
Tao JiangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China.ORCID 0000-0003-1908-2926
Changming YuAcademy of Military Medical Sciences, Beijing 100071, China.
Xiangyang ChiAcademy of Military Medical Sciences, Beijing 100071, China.ORCID 0000-0002-0580-5997

Funding

Beijing Rising Stars of Science and Technology Program 20240484733
6 · The paper itself

Abstract

Influenza A virus pandemics pose a persistent global health threat, and emerging antiviral resistance underscores the critical importance of developing novel broad-spectrum therapeutic agents. Building on licorice's (

Indexed as

Antiviral AgentsFlavonesInfluenza B virusNucleic Acid Synthesis InhibitorsOrthomyxoviridae InfectionsRNA-Dependent RNA PolymeraseAnimalsCell SurvivalDogsMadin Darby Canine Kidney CellsMolecular Docking SimulationProtein Structure, TertiaryVirus ReplicationAntiviral AgentsFlavoneslicoflavone BNucleic Acid Synthesis InhibitorsRNA-Dependent RNA Polymeraseantiviral treatmentinfluenza A virus (IAV)licoflavone BRNA-dependent RNA polymerase (RdRp)

Identifiers

PMID41012585
PMCPMC12474473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.