Evidence map›Paper›PMID 41012582›Full record

ArticleViruses2025

Gene Expression Factors Associated with Rubella-Specific Humoral Immunity After a Third MMR Vaccine Dose.

Lara I Teodoro, Iana H Haralambieva, Inna G Ovsyannikova, Krista M Goergen, Diane E Grill, Gregory A Poland, Richard B Kennedy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lara I TeodoroMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-5383-3709
Iana H HaralambievaMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.
Inna G OvsyannikovaMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-1506-9214
Krista M GoergenDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Diane E GrillDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Gregory A PolandMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.
Richard B KennedyMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-6164-4967

Funding

The Immunogenetics of Measles ImmunityR01AI033144 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 1993 to 2022
$8.1M
Immunogenetic Mechanisms of Vaccine ResponseR37AI048793 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2011 to 2020
$5.4M
Systems Biology of Mumps Vaccine ResponseR01AI138965 · NIAID · MAYO CLINIC ROCHESTER · PI KENNEDY, RICHARD B · 2018 to 2022
$3.9M
NIAID NIH HHS R01 AI033144NIAID NIH HHS R01 AI138965NIAID NIH HHS R37 AI048793NIH HHS 5R01AI033144-28NIH HHS 5R37AI048793-20NIH HHS R01AI138965
6 · The paper itself

Abstract

Rubella is typically a mild viral illness, but it can lead to severe complications when contracted during pregnancy, such as pregnancy loss or developmental defects in the fetus (congenital rubella syndrome). Therefore, it is crucial to develop and maintain protective immunity in women of childbearing age. In this study, we assessed the transcriptional factors associated with rubella-specific immune outcomes (IgG binding antibody and avidity, neutralizing antibody, and memory B cell ELISpot response) following a third MMR vaccine dose in women of reproductive age to identify key factors/signatures impacting the immune response. We identified baseline (Day 0) and differentially expressed (Day 28-Day 0) genes associated with several RV-specific immune outcomes, including the transferrin receptor 2 (

Indexed as

Immunity, HumoralMeasles-Mumps-Rubella VaccineRubellaRubella virusAdultAntibodies, NeutralizingAntibodies, ViralFemaleHumansImmunoglobulin GPregnancyYoung AdultAntibodies, NeutralizingAntibodies, ViralImmunoglobulin GMeasles-Mumps-Rubella Vaccinegene expressiongenetic markershumoral immunityimmunityMMRNGSRNArubellarubella vaccinetranscriptome

Identifiers

PMID41012582
PMCPMC12474309

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.