Evidence map›Paper›PMID 41012469›Full record

ReviewPharmaceutics2025

Photodynamic Therapy for Glioblastoma: Potential Application of TiO

Emma Ortiz-Islas, María Elena Manríquez-Ramírez, Pedro Montes, Citlali Ekaterina Rodríguez-Pérez, Elizabeth Ruiz-Sanchez, Karla Carvajal-Aguilera, Victoria Campos-Peña

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emma Ortiz-IslasLaboratorio de Neurofarmacología y Nanotecnología Molecular, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Mexico City 14269, Mexico.
María Elena Manríquez-RamírezLaboratorio de Investigación en Nanomateriales y Energías Limpias, ESIQIE-IPN, Instituto Politécnico Nacional, Lindavista 07700, Gustavo A. Madero CDMX, Mexico City 14269, Mexico.ORCID 0000-0003-3148-2527
Pedro MontesLaboratorio de Neuroinmunoendocrinología, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Mexico City 14269, Mexico.
Citlali Ekaterina Rodríguez-PérezLaboratorio de Neurofarmacología y Nanotecnología Molecular, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Mexico City 14269, Mexico.
Elizabeth Ruiz-SanchezLaboratorio de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Mexico City 14269, Mexico.ORCID 0000-0002-8184-0532
Karla Carvajal-AguileraLaboratorio de Nutrición Experimental, Instituto Nacional de Pediatria, Mexico City 04530, Mexico.
Victoria Campos-PeñaLaboratorio Experimental de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Mexico City 14269, Mexico.ORCID 0000-0001-8282-7543

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite aggressive current therapies against glioblastoma (GB), residual tumor cells may remain at the edge of the surgical cavity after resection. These cells can rapidly proliferate, giving rise to tumor recurrence in more aggressive and drug-resistant forms. As photodynamic therapy (PDT) has advanced, it has emerged as an option to treat this brain tumor. The oncological basis of PDT involves the selective accumulation of a photosensitizer (PS) in the tumor, followed by its activation with electromagnetic radiation to generate reactive oxygen species (ROS), which induce tumor cell death. Given that first- and second-generation PSs present significant limitations, including poor tumor selectivity, suboptimal biodistribution, limited absorption within the therapeutic window, and slow systemic clearance, research has progressed toward the development of third-generation PSs based on nanotechnology to optimize their therapeutic properties. This review addresses the types of tumor cell death induced by PDT, as well as the advancements of PS design, focusing on titanium dioxide (TiO

Indexed as

glioblastomananoparticlesphotodynamic therapyphotosensitizerstitanium dioxidezinc oxide

Identifiers

PMID41012469
PMCPMC12473035

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.