Evidence map›Paper›PMID 41012447›Full record

ArticlePharmaceutics2025

A Mechanistic Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach Informed by In Vitro and Clinical Studies for Topical Administration of Adapalene Gels.

Namrata S Matharoo, Harsha T Garimella, Thu M Truong, Saiaditya Badeti, Joyce X Cui, Sesha Rajeswari Talluri, Amitkumar Virani, Babar K Rao, Bozena Michniak-Kohn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Namrata S MatharooCenter for Dermal Research, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ 08854, USA.ORCID 0000-0002-8684-2318
Harsha T GarimellaCFD Research Corporation, 6820 Moquin Dr NW, Huntsville, AL 35806, USA.ORCID 0000-0003-3084-1989
Thu M TruongMontefiore Medical Center, Division of Dermatology, Bronx, NY 10461, USA.ORCID 0000-0002-6282-801X
Saiaditya BadetiDepartment of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-2885-2315
Joyce X CuiCenter for Dermal Research, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ 08854, USA.
Sesha Rajeswari TalluriCenter for Dermal Research, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ 08854, USA.
Amitkumar ViraniCenter for Dermal Research, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ 08854, USA.
Babar K RaoDepartment of Dermatology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Bozena Michniak-KohnCenter for Dermal Research, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ 08854, USA.

Funding

FDA HHS R43 FD005345FDA HHS R44 FD005345National Institutes of Health/U.S. Food and Administration under the Small Business Innovation Research (SBIR) grants Phase I: 1R43FD005345-01A1; Phase II: 2R44FD005345-02
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acne vulgarisadapalenebioequivalenceclinical studiesgelspermeation testingpharmacokinetic pharmacodynamic modelingphysiologically based pharmacokinetic modelingrelease testingretinoidstopical delivery

Identifiers

PMID41012447
PMCPMC12473830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.