Evidence map›Paper›PMID 41012410›Full record

ArticleToxics2025

Examination of DNA Methylation Patterns in Children Born Premature with Prenatal Tobacco Smoke Exposure.

Olivia E Gittens, Alonzo T Folger, Xue Zhang, Lili Ding, Nehal A Parikh, E Melinda Mahabee-Gittens

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Olivia E GittensMedical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Alonzo T FolgerDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0002-0849-723X
Xue ZhangDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Lili DingDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0003-2345-3726
Nehal A ParikhNeurodevelopmental Disorders Prevention Center, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
E Melinda Mahabee-GittensDivision of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0002-3893-885X

Funding

A New Model to Identify Preterm Neonates at High-Risk for Cognitive Impairments and School ReadinessR01NS094200 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI NEHAL A. PARIKH · 2016 to 2026
$6.7M
Prevalence and Clinical Correlates of Thirdhand Smoke Exposure in a Pediatric Patient PopulationR01ES030743 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI MAHABEE-GITTENS, E. MELINDA · 2019 to 2023
$2.9M
Early Prediction of Cerebral Palsy in Premature Infants using Advanced MRI BiomarkersR01NS096037 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI PARIKH, NEHAL A. · 2016 to 2020
$2.2M
NIEHS NIH HHS R01 ES030743NIEHS NIH HHS R01ES030743NINDS NIH HHS R01 NS094200NINDS NIH HHS R01 NS094200, R01 NS096037NINDS NIH HHS R01 NS096037
6 · The paper itself

Abstract

Prenatal tobacco smoke exposure (TSE) has been associated with significant alterations in DNA methylation (DNAm), an epigenetic mechanism with potential functional consequences to child development. This pilot study aimed to investigate differential DNAm patterns in preterm children with and without prenatal TSE using reduced representation bisulfite sequencing (RRBS) to interrogate a wider array of sites than in more common approaches, namely microarrays. Buccal swabs were collected from 16 two-year-old children (7 with TSE, 9 without), and DNAm was quantified at over 1.3 million CpG sites. To identify differential DNAm, univariable analyses were first performed and followed by Bayesian beta-binomial hierarchical regression models for sequence count data including adjustment for potential confounders. False Discovery Rate correction was used to account for multiple comparisons. Significant differential methylation was observed at CpG sites within intronic regions of the

Indexed as

CpG IslandsDNA methylationPreterm BirthReduced Representation Bisulfite SequencingTobacco Smoking

Identifiers

PMID41012410
PMCPMC12474237

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.