Evidence map›Paper›PMID 41012364›Full record

ReviewToxics2025

Trace Elements in Post-Mortem Tissues: A Review of Current Evidence and Forensic Challenges.

Claudia Trignano, Angela Sabalic, Andrea Pisano, Davide Tutedde, Pablo Hernández-Camarero, Raffaele La Russa, Macarena Perán, Roberto Madeddu

Abstract readReview
In one paragraph

Review in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Claudia TrignanoDepartment of Biomedical Science, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-8846-0700
Angela SabalicDepartment of Biomedical Science, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-9352-6161
Andrea PisanoDepartment of Biomedical Science, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0001-6050-2756
Davide TuteddeDepartment of Biomedical Science, University of Sassari, 07100 Sassari, Italy.ORCID 0009-0009-4515-1885
Pablo Hernández-CamareroDepartment of Health Sciences, University of Jaén, Campus de las Lagunillas, E-23071 Jaén, Spain.
Raffaele La RussaDepartment of Clinical Medicine, Public Health, Life Sciences, Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0003-3433-7122
Macarena PeránDepartment of Health Sciences, University of Jaén, Campus de las Lagunillas, E-23071 Jaén, Spain.ORCID 0000-0001-7562-2347
Roberto MadedduDepartment of Biomedical Science, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-2016-0357

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTrace elements and heavy metals can provide valuable forensic information for individual identification, lifestyle reconstruction, and association with the scene or time of death and may also assist in linking objects to criminal activities. However, the lack of standardized guidelines and post-mortem reference values represents a significant limitation in forensic investigations.

methodsThis review was conducted in accordance with the PRISMA statement. We performed a comprehensive literature study over the last ten years focusing on the analysis of trace elements and heavy metals in post-mortem tissues.

resultsThe search results from the databases yielded 247 records. The screening, according to PRISMA criteria, allowed us to select and include 19 articles. The results showed the need for standardized guidelines and reference values. Although post-mortem trace element analysis shows high potential for forensic applications, substantial methodological heterogeneity persists. Some studies have proposed preliminary reference values for cadmium (Cd) in kidneys and mercury (Hg) in hair but validated post-mortem reference ranges remain largely unavailable.

conclusionsThe current literature demonstrates the forensic potential of trace element and heavy metals analysis including Cd, Hg, lead (Pb), Manganese (Mn), Aluminum (Al), Copper (Cu), Zinc (Zn), Iron (Fe), Thallium (Tl), Polonium (

Indexed as

autopsyforensic investigationforensic toxicologyheavy metalsICP-IMSpostmortem analysispostmortem samplestrace elements

Identifiers

PMID41012364
PMCPMC12473529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.