ArticleToxics2025
Cytotoxic Effects and Micronuclei Frequency as a Biomarker of Genotoxicity in Farmers from the Municipality of Tehuacán, Puebla, Mexico.
Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Formulation Matters: Differential Genotoxic and Cytotoxic Effects of Lambda-Cyhalothrin Pesticide Formulations on Human Hepatocellular Cells.Journal of xenobiotics · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
In Tehuacán, Puebla, Mexico, the agricultural sector is primarily dedicated to corn cultivation, which is reflected in the region's economy, culture, and diet. This sector follows an agro-industrial production model dependent on pesticides and chemical fertilizers, which impacts both soil health and the population's well-being. The objective of this study was to assess cytotoxic damage using the Buccal Micronucleus Cytome Assay (BMCA) in a population engaged in agricultural activities in San Diego Chalma, Tehuacán, Puebla, Mexico. Sociodemographic parameters were analyzed, along with the buccal micronucleus cytome assay, in a sample of 35 individuals composed of an agricultural group (18) and a control group (17). The agricultural group showed a significantly higher number of total micronucleated cells (Median = 714), which was 19.8 times greater than the non-agricultural group. Age, sex, basic education level, time of residence, and involvement in agricultural activities were key factors contributing to the development of buccal cell micronuclei, in addition to the use of pesticides as lambda-cyhalothrin, spinetoram, ethoprophos, carbofuran, methomyl, and chlorpyrifos ethyl without safety measures. There was an increased risk of developing micronucleated cells in males from the control group (OR = 2.386, 95% CI = 2.123-2.681) and in individuals aged 30-59 years (OR = 16.464, 95% CI = 14.315-18.935). The agricultural population for the 0-29 years presented a risk probability developing micronucleated cells of 99.8% in men and 99.9% in women, with a higher risk observed in women and in individuals who had lived their entire lives in San Diego Chalma, where they are continuously exposed to pesticides. Therefore, it is crucial to provide guidance, training, and improved public policies in the region of Puebla, Mexico.
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