ReviewToxics2025
A Scoping Review on Male-Mediated Developmental Toxicity.
Review in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDevelopmental toxicity is defined as adverse effects induced either during pregnancy or as a result of parental exposure. While considerable attention has been devoted to maternal exposure to such chemicals, the role of paternal exposure has often been regarded as less significant.
objectiveThis study aims to highlight the impact of male-mediated developmental toxicity.
methodsAn online search was conducted using PubMed, Scopus, and Google Scholar to identify studies focusing on developmental toxicity in offspring associated with paternal exposure during the preconception period.
resultsThe scientific literature-ranging from studies on pharmaceutical use to substances of abuse (notably tobacco, alcohol, opioids, and cannabinoids), as well as occupational and environmental exposure to specific compounds (e.g., phthalates, certain organic solvents, pesticides)-indicates that paternal exposure to developmental toxicants can adversely affect offspring health through various biochemical mechanisms.
conclusionsThere is substantial experimental evidence of male-mediated developmental toxicity for various chemicals, demonstrating a particular vulnerability of the male germ line to transmissible effects. Several mechanisms have been proposed to explain the biochemical pathways underlying this toxicity. Evidence in humans is more challenging to interpret; however, numerous findings-both concerning substances of abuse and occupational exposures-raise concerns regarding the potential developmental risks to offspring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.