Green Synthesis of Zwitterionic-Cyclodextrin Hybrid Polymer for Efficient Extraction of Polypeptides: Combination of Instrumental Analysis and DFT Calculation.

Xiaoyun Lei, Xin Wang, Yuzhe Cao, Bingxing Ren, Yanyan Peng, Hanghang Zhao

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Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Xiaoyun LeiShaanxi Key Laboratory of Catalysis, School of Chemical and Environmental Science, Shaanxi University of Technology, Hanzhong 723001, China.

Xin WangShaanxi Key Laboratory of Catalysis, School of Chemical and Environmental Science, Shaanxi University of Technology, Hanzhong 723001, China.

Yuzhe CaoShaanxi Key Laboratory of Catalysis, School of Chemical and Environmental Science, Shaanxi University of Technology, Hanzhong 723001, China.

Bingxing RenShaanxi Key Laboratory of Catalysis, School of Chemical and Environmental Science, Shaanxi University of Technology, Hanzhong 723001, China.

Yanyan PengShaanxi Key Laboratory of Catalysis, School of Chemical and Environmental Science, Shaanxi University of Technology, Hanzhong 723001, China.

Hanghang ZhaoShaanxi Key Laboratory of Catalysis, School of Chemical and Environmental Science, Shaanxi University of Technology, Hanzhong 723001, China.

Funding

DOCTOR RESEARCH START FOUNDATION OF 454 SHAANXI UNIVERSITY OF TECHNOLOGY SLGRCQD004

6 · The paper itself

Abstract

Adhering to the principles of green analytical chemistry (GAC) is crucial for advancing sample pretreatment. In this work, we developed a green in-tube solid-phase microextraction (IT-SPME) material utilizing non-toxic cyclodextrin and zwitterionic polymers as co-functioning monomers. The hybrid monolithic material was synthesized within 38 min via an efficient epoxy ring-opening reaction and free radical polymerization. Comprehensive characterization confirmed a rigid framework with strong anti-swelling properties, good permeability, and high enrichment efficiency on the polymers. When coupled with HPLC-UV, the optimized IT-SPME method enabled highly sensitive detection of polypeptides (vancomycin and teicoplanin) in aqueous matrices, achieving detection limits as low as 15.0-20.0 μg L

Indexed as

density functional theory (DFT) calculationsgreen analytical chemistry (GAC)in-tube solid-phase microextraction (IT-SPME)zwitterionic–cyclodextrin polymer

Identifiers

PMID41012285

DOI10.3390/polym17182524

PMCPMC12473841

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