Evidence map›Paper›PMID 41012219›Full record

ArticlePolymers2025

Engineering Poly(L-Lactic Acid)/Hydroxyapatite Scaffolds via Melt-Electrowriting: Enhancement of Osteochondral Cell Response in Human Nasal Chondrocytes.

Valentina Basoli, Vittorio Barbano, Cecilia Bärtschi, Cosimo Loffreda, Matteo Zanocco, Alfredo Rondinella, Alex Lanzutti, Wenliang Zhu, Stefania Specchia, Andrea Barbero and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Valentina BasoliMedical Additive Manufacturing Research Group (Swiss MAM), Department of Biomedical Engineering, University of Basel, Hegenheimermattweg 167C, 4123 Allschwil, Switzerland.ORCID 0000-0002-4703-7308
Vittorio BarbanoCeramic Physics Laboratory, Faculty of Materials Science and Engineering, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, Kyoto 606-8585, Japan.ORCID 0009-0007-0945-5895
Cecilia BärtschiMedical Additive Manufacturing Research Group (Swiss MAM), Department of Biomedical Engineering, University of Basel, Hegenheimermattweg 167C, 4123 Allschwil, Switzerland.
Cosimo LoffredaMedical Additive Manufacturing Research Group (Swiss MAM), Department of Biomedical Engineering, University of Basel, Hegenheimermattweg 167C, 4123 Allschwil, Switzerland.
Matteo ZanoccoDepartment Polytechnic of Engineering and Architecture, University of Udine, Via delle Scienze, 206, 33100 Udine, Italy.ORCID 0000-0002-3825-7245
Alfredo RondinellaDepartment Polytechnic of Engineering and Architecture, University of Udine, Via delle Scienze, 206, 33100 Udine, Italy.
Alex LanzuttiDepartment Polytechnic of Engineering and Architecture, University of Udine, Via delle Scienze, 206, 33100 Udine, Italy.ORCID 0000-0002-3256-3516
Wenliang ZhuCeramic Physics Laboratory, Faculty of Materials Science and Engineering, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, Kyoto 606-8585, Japan.ORCID 0000-0001-7532-9714
Stefania SpecchiaPolitecnico di Torino, Department of Applied Science and Technology, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.ORCID 0000-0003-3882-3240
Andrea BarberoDepartment of Biomedicine, University of Basel, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland.ORCID 0000-0001-5252-789X
Florian Markus ThieringerMedical Additive Manufacturing Research Group (Swiss MAM), Department of Biomedical Engineering, University of Basel, Hegenheimermattweg 167C, 4123 Allschwil, Switzerland.ORCID 0000-0003-3035-9308
Huaizhong XuDepartment of Biobased Materials Science, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, Kyoto 606-8585, Japan.
Elia MarinCeramic Physics Laboratory, Faculty of Materials Science and Engineering, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, Kyoto 606-8585, Japan.ORCID 0000-0002-0981-7821

Funding

Asia Leading House, funded by the Swiss State Secretariat for Education, Research and Innovation (SERI) P.320.1031European Union and SERI (State Secretariat for Education, Research and Innovation, Switzerland) m2M on"A Bioprinting Platform for the Rapid, Reliable, Controlled, and Quantifiable Patterning of Cellular Aggregates and Microtissues into Macroscale Regener 101191729L-INSIGHT Program (Program for the next generation leading researchers with global insight) NAWarner-Siemens Foundation - Miracle II NA
6 · The paper itself

Abstract

Osteochondral repair remains challenging due to cartilage's limited self-healing capacity and the structural complexity of the osteochondral interface, particularly the hypertrophic layer anchoring cartilage to bone. We fabricated melt electrowritten (MEW) poly(L-lactic acid) (PLLA) scaffolds incorporating 1%, 5%, and 10% hydroxyapatite (HAp) to provide a precise fiber architecture (~200 μm pores) and bone-mimetic biochemical cues. Human nasal chondrocytes (hNCs), currently in clinical trials for knee cartilage repair, were selected for their phenotypic plasticity and established safety profile, facilitating translational potential. HAp-PLLA scaffolds, especially at higher HAp contents, enhanced hNC adhesion, proliferation, mineralization, and maintenance of cartilage-specific ECM compared to PLLA alone. This work demonstrates the first high-HAp MEW-printed PLLA scaffold for osteochondral repair, integrating architectural precision with bioactivity in a clinically relevant cell-material system.

Indexed as

bone guide regeneration membrane scaffoldscellular proliferationelectrospinninghydroxyapatitepoly(L-lactic acid)tissue engineering

Identifiers

PMID41012219
PMCPMC12473345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.