Evidence map›Paper›PMID 41012189›Full record

ArticleVaccines2025

Visual Detection of Malaria Parasite-Parasitized Erythroblasts in Peripheral Blood via Immunization-Based Model.

Kumpei Ito, Yuki S Tateishi, Takashi Imai, Shinya Miyazaki, Yukiko Miyazaki, Wataru Kagaya, Mai Nakashima, Miho Sase, Misato Yoshioka-Takeda, Chikako Shimokawa and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kumpei ItoDepartment of Parasitology, National Institute of Infectious Diseases (NIID), Japan Institute for Health Security (JIHS), Tokyo 162-0052, Japan.ORCID 0009-0000-1346-4611
Yuki S TateishiDepartment of Parasitology, National Institute of Infectious Diseases (NIID), Japan Institute for Health Security (JIHS), Tokyo 162-0052, Japan.
Takashi ImaiDepartment of Parasitology, National Institute of Infectious Diseases (NIID), Japan Institute for Health Security (JIHS), Tokyo 162-0052, Japan.ORCID 0000-0001-9049-8102
Shinya MiyazakiDepartment of Protozoology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0000-0001-9765-9757
Yukiko MiyazakiDepartment of Protozoology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.
Wataru KagayaDepartment of Ecoepidemiology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0000-0003-0998-5267
Mai NakashimaDepartment of Molecular Protozoology, Research Institute for Microbial Diseases (RIMD), Osaka University, Osaka 565-0871, Japan.
Miho SaseDepartment of Parasitology, National Institute of Infectious Diseases (NIID), Japan Institute for Health Security (JIHS), Tokyo 162-0052, Japan.ORCID 0009-0003-8341-2747
Misato Yoshioka-TakedaDepartment of Parasitology, National Institute of Infectious Diseases (NIID), Japan Institute for Health Security (JIHS), Tokyo 162-0052, Japan.ORCID 0009-0003-0664-4659
Chikako ShimokawaDepartment of Parasitology, National Institute of Infectious Diseases (NIID), Japan Institute for Health Security (JIHS), Tokyo 162-0052, Japan.ORCID 0000-0002-5421-5344
Kyoko HayashiDepartment of Parasitology, National Institute of Infectious Diseases (NIID), Japan Institute for Health Security (JIHS), Tokyo 162-0052, Japan.
Kentaro ItokawaAntimicrobial Resistance Research Center, National Institute of Infectious Diseases (NIID), Japan Institute for Health Security (JIHS), Tokyo 189-0002, Japan.ORCID 0000-0003-1300-9883
Osamu KomagataAntimicrobial Resistance Research Center, National Institute of Infectious Diseases (NIID), Japan Institute for Health Security (JIHS), Tokyo 189-0002, Japan.ORCID 0000-0002-8175-6402
Ha Ngo-ThanhDepartment of Infectious Diseases and Host Defense, Gunma University, Maebashi 371-8511, Japan.
Aoi ShimoDepartment of Parasitology, National Institute of Infectious Diseases (NIID), Japan Institute for Health Security (JIHS), Tokyo 162-0052, Japan.
Tamasa ArakiDepartment of Parasitology, National Institute of Infectious Diseases (NIID), Japan Institute for Health Security (JIHS), Tokyo 162-0052, Japan.ORCID 0000-0002-0316-8242
Takeshi AnnouraDepartment of Parasitology, National Institute of Infectious Diseases (NIID), Japan Institute for Health Security (JIHS), Tokyo 162-0052, Japan.
Takashi MurakamiDepartment of Microbiology, Saitama Medical University, Saitama 350-0495, Japan.
Hajime HisaedaDepartment of Parasitology, National Institute of Infectious Diseases (NIID), Japan Institute for Health Security (JIHS), Tokyo 162-0052, Japan.

Funding

Japan Agency for Medical Research and Development JP25fk0108681
6 · The paper itself

Abstract

backgroundErythroblasts have recently been identified as host cells for malarial parasites, revealing a previously underappreciated host-parasite interaction. However, their extremely low abundance in peripheral blood has hindered progress, especially in elucidating the biological significance of parasitized erythroblasts (pEBs)

methodsHere, we visualized pEBs in a murine model and established a method to increase their number in peripheral blood by immunizing mice with live

resultsImmunized mice were protected from cerebral malaria and survived longer, during which pEBs appeared in circulation and were detected using Giemsa-stained smears. All blood-stage parasite forms were identified within pEBs, including enucleating erythroblasts.

conclusionsThis model enables

Indexed as

erythroblastGiemsa stainingmalariaPlasmodium bergheivaccine model

Identifiers

PMID41012189
PMCPMC12474172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.