Evidence map›Paper›PMID 41012187›Full record

ArticleVaccines2025

Oral Vaccination with

Na Jiang, Zhihong Ma, Jinjing Zhang, Lin Luo, Xingchen Huo, Jufeng Jiang, Jian Gao, Jie Huang, Dongjie Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Na JiangFisheries Science Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100068, China.
Zhihong MaFisheries Science Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100068, China.
Jinjing ZhangFisheries Science Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100068, China.
Lin LuoFisheries Science Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100068, China.
Xingchen HuoFisheries Science Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100068, China.
Jufeng JiangTianjin Fisheries Research Institute, Tianjin Ornamental Fish Technology and Engineering Centre, Tianjin 300221, China.
Jian GaoCollege of Fisheries, Huazhong Agricultural University, Wuhan 430070, China.
Jie HuangFisheries Science Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100068, China.
Dongjie ShiFisheries Science Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100068, China.

Funding

Beijing Municipal Bureau of Agriculture and Rural Affairs' Agricultural Product Quality and Safety Project NO11000024T000002865825Special funds for the National Engineering Research Center for Freshwater Fisheries (Beijing), Ministry of Agriculture and Rural Affairs PT2025-19
6 · The paper itself

Abstract

BACKGROUND/

objectives

methodsThis study aimed to validate the efficacy of bacterial ghosts as an oral vaccine by administering them to

resultsOral vaccination with bacterial ghosts led to the significant enhancement of lysozyme (LZM) and myeloperoxidase (MPO) activity in koi serum. It also resulted in the upregulation of cytokines, such as IL-2 and TNF-α, as well as an increase in both systemic (IgM) and mucosal (IgZs) antibody responses. The immunized group demonstrated reduced cumulative mortality following bacterial challenge. The relative percent survival in the vaccinated group reached as high as 87.50%.

conclusionsThe oral immunization of

Indexed as

acquired immuneAeromonas veroniibacterial ghostinnate immuneoral vaccination

Identifiers

PMID41012187
PMCPMC12474343

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.