Evidence map›Paper›PMID 41012166›Full record

ArticleVaccines2025

Cord Blood RSV-Neutralizing Antibodies and Risk of Hospitalization for RSV-Associated Acute Respiratory Infection in Vietnamese Children: A Case-Cohort Study.

Michiko Toizumi, Yutaro Yamagata, Hien Anh Thi Nguyen, Hirono Otomaru, Hoang Huy Le, Hiroyuki Moriuchi, Jean-Francois Eleouet, Marie-Anne Rameix-Welti, Makoto Takeda, Hung Thai Do and 1 more

Abstract read
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In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michiko ToizumiDepartment of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0000-0002-8401-9344
Yutaro YamagataDepartment of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0009-0009-4741-7245
Hien Anh Thi NguyenNational Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.
Hirono OtomaruDepartment of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0009-0001-7397-774X
Hoang Huy LeNational Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.
Hiroyuki MoriuchiNational Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0000-0001-7448-8115
Jean-Francois EleouetUnité de Virologie et Immunologie Moléculaires (VIM), Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), Université Paris-Saclay, 78350 Jouy-en-Josas, France.ORCID 0000-0002-7361-4885
Marie-Anne Rameix-WeltiMolecular Mechanisms of Multiplication of Pneumoviruses Unit (M3P), Institut Pasteur, Université Paris-Saclay, Université de Versailles St. Quentin, Université Paris Cité, UMR 1173 (2I), INSERM, Centre National de Reference Virus des Infections Respiratoires (CNR VIR), Assistance Publique des Hôpitaux de Paris, 75015 Paris, France.ORCID 0000-0002-5901-3856
Makoto TakedaFaculty of Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0002-8194-7727
Hung Thai DoDepartment of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0000-0003-2097-7364
Lay-Myint YoshidaDepartment of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0000-0002-7567-3248

Funding

Japan Program for Infectious Diseases Research and Infrastructure, Japan Agency for Medical Research and Development (AMED) JP21wm0125006the Japan Society for the Promotion of Science (JSPS), KAKENHI 16H05846, JP22K17348
6 · The paper itself

Abstract

backgroundRespiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in children, particularly severe during infancy. Maternal RSV-specific neutralizing antibodies (nAbs), transferred via the placenta, may provide protection in early infancy, but the extent and duration of protection remain uncertain.

objectiveWe investigated the association between cord blood RSV-A nAb levels and the risk of hospitalization due to RSV-associated acute respiratory infection (RSV-ARI) by 24 months of age.

methodsWe conducted a case-cohort study nested within a birth cohort in Nha Trang, Vietnam. From the full cohort (

resultsThe incidence of RSV-ARI hospitalization was 17.92 per 1000 person-years by 24 months, and 25.40 per 1000 person-years among infants aged <12 months. Among infants aged <6 months, those in the low nAb group had a significantly higher risk of hospitalization compared to the middle nAb group (adjusted HR: 4.05; 95% CI: 1.51-10.89). Maternal anemia was consistently associated with increased risk.

conclusionsLower RSV-nAb titers at birth were associated with an increased risk of RSV-ARI hospitalization during early infancy. These findings support the importance of maternal immunization strategies to enhance infant protection against RSV.

Indexed as

case–cohort studycord bloodinfantsmaternal antibodiesmaternal immunizationneutralizing antibodiesrespiratory syncytial virus

Identifiers

PMID41012166
PMCPMC12474007

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.