Evidence map›Paper›PMID 41012147›Full record

ArticleVaccines2025

CXCR5 Signals Fine-Tune Dendritic Cell Transcription and Regulate T

Miranda L Curtiss, Natalia Ballesteros Benavides, Alexander F Rosenberg, Christopher D Scharer, Beatriz León, Frances E Lund

Abstract read
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Miranda L CurtissDivision of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-5118-2279
Natalia Ballesteros BenavidesDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Alexander F RosenbergDepartment of Biomedical Informatics and Data Science, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0001-7716-8504
Beatriz LeónDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-3793-3854
Frances E LundDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-3083-1246

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Controlling Th2 immunity by tuning CXCL13 dependent DC migration in lymph nodesR01AI104725 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUND, FRANCES E. · 2013 to 2017
$1.8M
ALA/AAAAI Allergic Respiratory Disease Research Award 699115NCI NIH HHS P30 CA013148NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI104725NIH/NIAID 1R01AI104725
6 · The paper itself

Abstract

BACKGROUND/

objectivesWe previously demonstrated that dendritic cell (DC) expression of CXCR5 is required for T

methodsWe used

resultsWe showed that migratory conventional type 2 dendritic cells (cDC2) express CXCR5 and that deletion of

conclusionsCXCR5 expressed by cDC2 cells is required for induction of

Indexed as

Chi3l1CXCR5dendritic cellshelminth infectionTH2 responses

Identifiers

PMID41012147
PMCPMC12474269

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.