ArticleVaccines2025
Evaluation of T-Cell Responses Following Sequential Vaccination with PCV13 and PPSV23 Against
Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
Funding
Abstract
backgroundCharacterization of cellular responses to vaccinations in immunocompromised patients remains an evolving area of research. This particularly applies for pneumococcal vaccination in diseases such as psoriasis and in the setting of immunosuppressive therapy.
methodsThis prospective study included 42 patients with moderate-to-severe psoriasis. Following German guidelines at the time, patients underwent a sequential vaccination protocol against
resultsPatients undergoing anti-TNF-α blocker therapy, monoclonal antibody therapy (specifically anti-IL-12/23, IL-23, and IL-17), and methotrexate therapy showed significantly different responses to the pneumococcal serotype PS14 at onset (
conclusionsImmunosuppressive therapy alters vaccination-induced cellular immunity in psoriasis patients. Further research is needed to clarify the mechanisms involved.
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