Evidence map›Paper›PMID 41012106›Full record

ReviewVaccines2025

Nanovaccines: Innovative Advances from Design Strategies to Clinical Translation.

Jiuxiang He, Wen Xiao, Dong Hua, Minchi Liu, Hongxia Guo, Li Xu, Meiling Xiao, Yunsha Du, Jintao Li

Abstract readReview
In one paragraph

Review in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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  7. Nanovaccines for lung cancer: Platforms, mechanistic insights, and translational challenges.Chinese medical journal pulmonary and critical care medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiuxiang HeDepartment of Biosafety, College of Basic Medicine, Army Medical University, Chongqing 400038, China.
Wen XiaoDepartment of Biosafety, College of Basic Medicine, Army Medical University, Chongqing 400038, China.
Dong HuaDepartment of Biosafety, College of Basic Medicine, Army Medical University, Chongqing 400038, China.
Minchi LiuDepartment of Biosafety, College of Basic Medicine, Army Medical University, Chongqing 400038, China.
Hongxia GuoDepartment of Biosafety, College of Basic Medicine, Army Medical University, Chongqing 400038, China.
Li XuDepartment of Biosafety, College of Basic Medicine, Army Medical University, Chongqing 400038, China.
Meiling XiaoDepartment of Biosafety, College of Basic Medicine, Army Medical University, Chongqing 400038, China.
Yunsha DuDepartment of Biosafety, College of Basic Medicine, Army Medical University, Chongqing 400038, China.
Jintao LiDepartment of Biosafety, College of Basic Medicine, Army Medical University, Chongqing 400038, China.ORCID 0000-0003-3637-2386

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanovaccines have emerged as a transformative platform in immunotherapy, distinguished by their capabilities in targeted antigen delivery, enhanced immunogenicity, and multifunctional integration. By leveraging nanocarriers, these vaccines achieve precise antigen transport, improve immune activation efficiency, and enable synergistic functions such as antigen protection and adjuvant co-delivery. This review comprehensively explores the foundational design principles of nanovaccines, delves into the diversity of nanovaccine design strategies-including the selection of primary carrier materials, functionalization modification, synergistic delivery of immune adjuvants, and self-assembled nano-delivery systems-and highlights their applications in cancer immunotherapy, infectious disease and autoimmune diseases. Furthermore, it critically examines existing technical challenges and translational barriers, providing an integrative reference to guide future research and development in this dynamic field.

Indexed as

cancer immunotherapyimmunogenicityinfectious diseasesnanovaccinestargeted delivery

Identifiers

PMID41012106
PMCPMC12474465

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.