Evidence map›Paper›PMID 41011787›Full record

ArticlePathogens (Basel, Switzerland)2025

Differential Gene Expression and Protein-Protein Interaction Networks in Bovine Leukemia Virus Infected Cattle: An RNA-Seq Study.

Ana S González-Méndez, Mohammad Mehdi Akbarin, Fernando Cerón-Téllez, Gabriel Eduardo Acevedo-Jiménez, Cecilia Rodríguez-Murillo, Víctor David González-Fernández, Lucero de María Ávila-De la Vega, Marisela Leal-Hernández, Hugo Ramírez Álvarez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ana S González-MéndezNational Center for Disciplinary Research in Animal Health and Food Safety, National Institute of Forestry, Agriculture and Livestock Research (INIFAP), Mexico City 05110, CP, Mexico.
Mohammad Mehdi AkbarinVirology, Genetics, and Molecular Biology Laboratory, Faculty of Higher Studies Cuautitlán, Veterinary Medicine, Campus 4, National Autonomous University of Mexico, Cuautitlan Izacalli 54714, EM, Mexico.ORCID 0000-0002-1583-891X
Fernando Cerón-TéllezNational Center for Disciplinary Research in Animal Health and Food Safety, National Institute of Forestry, Agriculture and Livestock Research (INIFAP), Mexico City 05110, CP, Mexico.
Gabriel Eduardo Acevedo-JiménezVirology, Genetics, and Molecular Biology Laboratory, Faculty of Higher Studies Cuautitlán, Veterinary Medicine, Campus 4, National Autonomous University of Mexico, Cuautitlan Izacalli 54714, EM, Mexico.ORCID 0000-0002-2026-9918
Cecilia Rodríguez-MurilloVirology, Genetics, and Molecular Biology Laboratory, Faculty of Higher Studies Cuautitlán, Veterinary Medicine, Campus 4, National Autonomous University of Mexico, Cuautitlan Izacalli 54714, EM, Mexico.ORCID 0000-0003-4473-1588
Víctor David González-FernándezVirology, Genetics, and Molecular Biology Laboratory, Faculty of Higher Studies Cuautitlán, Veterinary Medicine, Campus 4, National Autonomous University of Mexico, Cuautitlan Izacalli 54714, EM, Mexico.
Lucero de María Ávila-De la VegaVirology, Genetics, and Molecular Biology Laboratory, Faculty of Higher Studies Cuautitlán, Veterinary Medicine, Campus 4, National Autonomous University of Mexico, Cuautitlan Izacalli 54714, EM, Mexico.
Marisela Leal-HernándezNational Center for Disciplinary Research in Animal Health and Food Safety, National Institute of Forestry, Agriculture and Livestock Research (INIFAP), Mexico City 05110, CP, Mexico.
Hugo Ramírez ÁlvarezVirology, Genetics, and Molecular Biology Laboratory, Faculty of Higher Studies Cuautitlán, Veterinary Medicine, Campus 4, National Autonomous University of Mexico, Cuautitlan Izacalli 54714, EM, Mexico.ORCID 0000-0003-1682-8104

Funding

Universidad Nacional Autónoma de México C12478Universidad Nacional Autónoma de México IN205021Universidad Nacional Autónoma de México IN206924
6 · The paper itself

Abstract

introductionBovine leukemia virus is a single-stranded RNA virus that targets B cell CD5

methodEighteen samples were selected, and their RNA was sequenced. For gene expression analysis and protein-protein network interactions, three groups were selected, including healthy negative samples (CT, n = 7), asymptomatic carriers (AC, n = 5), and persistent lymphocytosis (PL, n = 6), to provide the differentially expressed gene (DEG) and protein-protein interaction network (PPIN) outputs.

resultsOur results demonstrated that in comparison to CT, ACs upregulated TLR7 and transcription activation factors. In the CT vs. PL group,

conclusionsOur results suggest that innate and cellular immune responses are more loose in severe BLV infectious conditions, while the PPINs revealed that new protein interactions are necessary for oncogenesis.

Indexed as

Enzootic Bovine LeukosisLeukemia Virus, BovineProtein Interaction MapsAnimalsCattleGene Expression ProfilingGene Expression RegulationRNA-Seqasymptomatic carrierbovine leukemia viruspersistence lymphomaprotein–protein interaction networksRNA-seq

Identifiers

PMID41011787
PMCPMC12472682

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.