ArticlePathogens (Basel, Switzerland)2025
Global Burden and Incidence Trends in Cancers Associated with Human Papillomavirus Infection: A Population-Based Systematic Study.
Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Intratumoral Human Papillomavirus in Advanced Prostate Cancer: Systematic Review, Meta-Analysis, and Real-World Evidence from the Largest Cohort to Date.International journal of molecular sciences · 2026Pooled it
- Prevalence of cervical human papillomavirus infection among women in Ghana: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- Human papillomavirus awareness and vaccination willingness among male community residents in Beijing based on the Health Belief Model.Human vaccines & immunotherapeutics · 2026Article
- Survival outcomes of postoperative radiotherapy and chemotherapy in early-stage cervical cancer: a Surveillance, Epidemiology, and End Results database-based stratified analysis.Translational cancer research · 2026Article
- Head and neck cancer: a comprehensive review of epidemiology, global burden and advances in radiotherapy.Journal of the Egyptian National Cancer Institute · 2026Review
- Evaluating the Impact of an Educational Intervention on Medical Students' Knowledge and Attitudes Toward Human Papillomavirus.Journal of community health · 2026Article
- Article
- Review
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- Comparative performance of L1- and E6/E7-targeted HPV genotyping assays based on a unified MeltArray platform.Microbiology spectrum · 2026Article
- High-risk human papillomavirus positivity and associated factors among women living with HIV in public health facilities of Mekelle, Northern Ethiopia.Infectious agents and cancer · 2026Article
- A theory of planned behavior-based analysis of factors associated with human papillomavirus vaccination intentions among high school students in South Korea: a cross-sectional study.Child health nursing research · 2026Article
- Association Between Human Papillomavirus Vaccination and the Risk of Cervical Cancer and Precancerous Lesions in Israel: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- In Silico Design and Characterization of a Rationally Engineered Cas12j2 Gene Editing System for the Treatment of HPV-Associated Cancers.International journal of molecular sciences · 2026Article
- Assessing the impact of a gender-neutral approach to HPV vaccination on vaccination coverage for nine-year-old girls in Cameroon: A retrospective, cross-sectional study.PLOS global public health · 2026Article
- Knowledge and awareness regarding human papillomavirus and its association with oropharyngeal cancer among the general population in Makkah, Saudi Arabia: a cross-sectional study.Frontiers in oncology · 2026Article
- A novel approach to HPV16 VLP construction and production with improved accessibility and particle sorting potential.Frontiers in molecular medicine · 2026Article
- Role of cyberchondria severity in the relationship between HPV awareness and vaccination status among adult women.BMC public health · 2025Article
- Study of the Knowledge, Attitudes and Practices of Students from Medical Majors Regarding HPV Infections and HPV Vaccines.Pathogens (Basel, Switzerland) · 2025Article
- Associations between english proficiency and HPV vaccine uptake among foreign-born men and women in the United States: a cross-sectional study using data from the National Health Interview Survey.BMC public health · 2025Article
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7 authors.
Funding
Abstract
backgroundHuman papillomavirus (HPV) is responsible for a substantial fraction of anogenital and head and neck cancers (HNC). HPV-related cancers cause a heavy burden globally, with disparities across different cancers. We aimed to present an up-to-date global view of the patterns and incidence trends among HPV-related cancers.
methodsWe collected data on HPV-related cancers from the GLOBOCAN 2022 database and the Cancer Incidence in Five Continents plus Compendium. Age-standardized incidence and mortality rate (ASIR and ASMR) were calculated to estimate the cancer burden. Spearman's correlation tests were used to evaluate the associations with the Human Development Index (HDI). Joinpoint regression was conducted to evaluate the incidence trends in ASIR.
resultsIn 2022, 1,505,394 HPV-related cancer cases and 755,303 deaths were newly estimated worldwide, corresponding to an overall ASIR and ASMR of 20.9 and 10.2 per 100,000 people, respectively. Africa had the highest ASIR and ASMR compared with Asia, accounting for the most new cases and deaths. The primary cause was cervical cancer (ASIR 14.1 per 100,000 people); however, HNC exhibited the largest number of cases (685,204 cases). The total rates of HPV-related cancers were 1.3 times higher for ASIR and nearly three times higher for ASMR in low-HDI countries than in very high-HDI countries. A decreasing trend was observed for the ASIR of cervical cancer in most studied countries, compared to the increasing trends in HNC in females and anal cancer in both sexes.
conclusionsThe global burden and trends of HPV-related cancers vary significantly among different cancer types according to region and sex. Particularly, cervical, HNC, and anal cancers should attract global attention. However, specific cancer types contributing to the heaviest burden should be identified at the country level to adjust resource allocation and improve access to quality health services.
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