Evidence map›Paper›PMID 41011778›Full record

ArticlePathogens (Basel, Switzerland)2025

Optimization of (Dithioperoxo)thiolate-Based Antifungal Agents for Triazole-Resistant

Surya Karuturi, Kaitlyn L Jobe, Melinda E Varney, Michael D Hambuchen, A R M Ruhul Amin, Timothy E Long

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Surya KaruturiDepartment of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, WV 25755, USA.
Kaitlyn L JobeDepartment of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, WV 25755, USA.
Melinda E VarneyDepartment of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, WV 25755, USA.
Michael D HambuchenDepartment of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, WV 25755, USA.
A R M Ruhul AminDepartment of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, WV 25755, USA.ORCID 0000-0001-9144-2960
Timothy E LongDepartment of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, WV 25755, USA.ORCID 0000-0003-0213-4726

Funding

Targeting oncogenic pathways for chemoprevention of head and neck cancer by FLLL12R15DE032063 · NIDCR · MARSHALL UNIVERSITY · PI AMIN, A.R.M. RUHUL · 2023 to 2023
$444k
Discovery of Disulfiram as an Anti-MRSA Antibiotic AdjuvantR15AI151970 · NIAID · MARSHALL UNIVERSITY · PI LONG, TIMOTHY EDWARD · 2020 to 2020
$434k
NIAID NIH HHS R15 AI151970NIDCR NIH HHS R15 DE032063NIH HHS 1R15AI151970-01
6 · The paper itself

Abstract

This investigation on novel antifungal agents featuring a thiol-reactive (dithioperoxo)thiolate chemical nucleus [-NC(S)S-SR] established that the optimal levels of fungal growth inhibition were achieved with thiomethyl-bound derivatives (R = Me). The most efficacious analogs had MIC

Indexed as

Antifungal AgentsAspergillus fumigatusDrug Resistance, FungalSulfhydryl CompoundsTriazolesCell LineCopperGlutathioneHumansMicrobial Sensitivity TestsVoriconazoleAntifungal AgentsCopperGlutathioneSulfhydryl CompoundsTriazolesVoriconazoleantifungalantimicrobial discoveryAspergillusdisulfides

Identifiers

PMID41011778
PMCPMC12472219

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.