Evidence map›Paper›PMID 41011766›Full record

ArticlePathogens (Basel, Switzerland)2025

Reoviral Hepatitis in Young Turkey Poults-An Emerging Problem.

Rahul Kumar, Mohamed Selim, Anibal G Armien, Sagar M Goyal, Fabio A Vannucci, Sidhartha Deshmukh, Robert E Porter, Sunil K Mor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rahul KumarMinnesota Veterinary Diagnostic Laboratory, Veterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA.ORCID 0000-0002-2970-4285
Mohamed SelimAnimal Disease Research & Diagnostic Laboratory, Veterinary and Biomedical Sciences Department, South Dakota State University, Brookings, SD 57007, USA.
Anibal G ArmienMinnesota Veterinary Diagnostic Laboratory, Veterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA.ORCID 0000-0002-1870-9945
Sagar M GoyalMinnesota Veterinary Diagnostic Laboratory, Veterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA.ORCID 0000-0002-7781-3080
Fabio A VannucciMinnesota Veterinary Diagnostic Laboratory, Veterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA.
Sidhartha DeshmukhMinnesota Veterinary Diagnostic Laboratory, Veterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA.
Robert E PorterMinnesota Veterinary Diagnostic Laboratory, Veterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA.
Sunil K MorMinnesota Veterinary Diagnostic Laboratory, Veterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA.ORCID 0000-0002-1112-088X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

From January 2019 to April 2020, the Minnesota Veterinary Diagnostic Laboratory (MVDL) received cases of hepatitis and spiking mortality in young turkey poults (average age 15.5 days) from multiple turkey-producing states. Meat-type turkeys were mainly affected, with a few cases in breeders. Of 188 cases, 88 (47.5%) tested positive for reovirus by virus isolation, with most of the positive cases from 7 to 14-day-old birds (n = 42). Gross lesions consisted of hepatosplenomegaly with acute, multifocal necrosis in both liver and spleen. Microscopically, liver sections showed congestion of hepatic sinusoids and necrotizing hepatitis with infiltration of lymphocytes, plasma cells, and macrophages. Reovirus was detected in liver samples by electron microscopy and in situ hybridization (ISH). Sections of spleen showed areas of necrosis with infiltration of the mixed population of inflammatory cells and depletion of lymphocytes. We consistently isolated reoviruses from livers and tentatively named the virus "Turkey Hepatitis Reovirus" (THRV). Phylogenetic analysis of the newly emerged THRVs revealed their clustering into four distinct groups. This study also highlighted the close antigenic relation between TARV and THRV compared to turkey enteritis reoviruses (TERVs), which shed light on the probable origin of this newly emerged pathotype. In summary, further molecular and pathogenicity studies are recommended on THRVs to help diagnose and control this serious variant.

Indexed as

Hepatitis, Viral, AnimalPoultry DiseasesReoviridaeReoviridae InfectionsTurkeysAnimalsLiverMinnesotaPhylogenySpleenhepatitislamenesslivermortalitypoultturkey hepatitis reovirusturkey reoviruses

Identifiers

PMID41011766
PMCPMC12472222

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.