Evidence map›Paper›PMID 41011763›Full record

ArticlePathogens (Basel, Switzerland)2025

γδ T Cells Mediate Protective Immunity Following Vaccination with an Insect-Based Chikungunya Fever Vaccine in Mice.

Leslie Rodriguez, Awadalkareem Adam, Huanle Luo, Samantha R Osman, Kenneth Plante, Shannan L Rossi, Scott C Weaver, Tian Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leslie RodriguezDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0009-0006-1685-2891
Awadalkareem AdamDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Huanle LuoDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-0367-6888
Samantha R OsmanDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-5011-3869
Kenneth PlanteDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-7485-3167
Shannan L RossiSealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0003-2450-2374
Scott C WeaverDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0001-8016-8556
Tian WangDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.

Funding

Project 5: mAb Development Flaviviruses and AlphavirusesU19AI181960 · NIAID · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S, KUHN, RICHARD J. · 2024 to 2024
$46.7M
Revolutionary Eilat-based Chikungunya Vaccine VectorR01AI127744 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WANG, TIAN · 2017 to 2021
$3.5M
Porous silicon microparticle-based subunit vaccines for SARS-CoV-2R01AI176670 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Tian Wang · 2023 to 2026
$2.7M
Role of microglia in neural infectionR01NS125778 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Tian Wang, Ping Wu · 2022 to 2026
$2.5M
NIAID NIH HHS R01 AI127744NIAID NIH HHS R01 AI176670NIAID NIH HHS U19 AI181960NIH HHS R01AI127744NIH HHS R01 AI176670NIH HHS R01 NS125778NIH HHS U19AI181960NINDS NIH HHS R01 NS125778University of Texas Medical Branch McLaughlin Predoctoral Fellowship
6 · The paper itself

Abstract

Eilat (EILV)/chikungunya virus (CHIKV) is a chimeric virus that contains the nonstructural proteins and cis-acting sequences of EILV and the structural proteins of CHIKV. EILV/CHIKV vaccination is known to protect with a single dose against wild-type (WT) CHIKV challenge in mice and non-human primates. The underlying immune mechanism of the vaccine-induced host protection remains unknown. γδ T cells react to WT CHIKV infection by controlling the virus-induced tissue inflammation and damage. Here, we found that γδ T cells contribute to EILV/CHIKV-induced host protection against WT CHIKV infection. TCRδ

Indexed as

Chikungunya FeverChikungunya virusReceptors, Antigen, T-Cell, gamma-deltaViral VaccinesAnimalsAntibodies, ViralCD8-Positive T-LymphocytesMiceMice, Inbred C57BLMice, KnockoutVaccinationAntibodies, ViralReceptors, Antigen, T-Cell, gamma-deltaViral Vaccinesantibodychikungunya virusprotective immunityT cellsvaccinesγδ T cells

Identifiers

PMID41011763
PMCPMC12472593

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.