ArticlePathogens (Basel, Switzerland)2025
SARS-CoV-2 Infection in Children: Revisiting Host-Virus Interactions Through Post-Infection Immune Profiling.
Catarina Gregório Martins, Miguel Ângelo-Dias, Maria de Jesus Chasqueira, Maria João Brito, Tiago Milheiro Silva, Maria Vitória Matos, Maria Teresa Lopes, Hélio Crespo, Mariana Mata, Luís Miguel Borrego and 1 more
Abstract read
In one paragraphArticle in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Catarina Gregório MartinsImmunology, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 1169-056 Lisboa, Portugal.ORCID 0000-0003-0353-0421 Miguel Ângelo-DiasImmunology, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 1169-056 Lisboa, Portugal.ORCID 0000-0001-9933-4075 Maria de Jesus ChasqueiraCHRC, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 1169-056 Lisboa, Portugal.ORCID 0000-0002-8015-7109 Maria João BritoUnidade de Infeciologia Pediátrica, Hospital D. Estefânia, Unidade Local de Saúde de São José, 1169-045 Lisboa, Portugal.ORCID 0000-0003-3816-5743 Tiago Milheiro SilvaUnidade de Infeciologia Pediátrica, Hospital D. Estefânia, Unidade Local de Saúde de São José, 1169-045 Lisboa, Portugal.
Maria Vitória MatosPatologia Clínica, Hospital D. Estefânia, Unidade Local de Saúde de São José, 1169-045 Lisboa, Portugal.
Maria Teresa LopesImmunology, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 1169-056 Lisboa, Portugal.
Hélio CrespoImmunology, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 1169-056 Lisboa, Portugal.
Mariana MataImmunology, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 1169-056 Lisboa, Portugal.
Luís Miguel BorregoImmunology, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 1169-056 Lisboa, Portugal.
Paulo PaixãoCHRC, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 1169-056 Lisboa, Portugal.ORCID 0000-0002-4294-0872 Funding
MSD Corp., division of Merck&Co.,Inc. (Kenilworth, NJ, USA IIS# 60687
6 · The paper itselfAbstract
Children with COVID-19 typically experience milder symptoms and lower hospitalization rates, though severe cases do occur. Understanding age-related immune responses is crucial for future preparedness. We characterized immune response dynamics to SARS-CoV-2 in 145 samples from 119 pediatric patients (<18 years) with confirmed infection, assessed at four distinct time points: <14 days, 14 days-3 months, 3-6 months, and 6-12 months post-infection. At infection, patients presented increased activated T-cells, higher levels of exhaustion (i.e., PD-1
Indexed as
COVID-19Host-Pathogen InteractionsSARS-CoV-2AdolescentAntibodies, ViralB-LymphocytesChildChild, PreschoolFemaleHumansImmunity, CellularInfantLymphocyte ActivationMaleMemory B CellsT-LymphocytesAntibodies, ViralB-cellschildrenCOVID-19immune profilespecific responsesT-cells
Identifiers
PMID41011738
PMCPMC12472562
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390