ReviewMolecules (Basel, Switzerland)2025
Development of Small-Diameter Silk Vascular Grafts Supported by Solid-State Nuclear Magnetic Resonance Structural Analysis.
Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Application of Transgenic Silk Fibroin to Biomaterials.Biotechnology and bioengineering · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review discusses the development of small-diameter silk-based vascular grafts, based on insights obtained through solid-state NMR structural analysis. With the increasing prevalence of cardiovascular diseases, the demand for vascular grafts with diameters of less than 6 mm is growing. Although synthetic grafts currently used in clinical settings-such as polyethylene terephthalate and expanded polytetrafluoroethylene-are effective, they tend to cause thrombosis and intimal hyperplasia when used as small-diameter vascular grafts. In response to this issue, research has been advancing on new materials that maintain excellent mechanical properties while improving biocompatibility. This review first describes how the detailed structure of silk fibroin (SF) before and after fiber formation was revealed for the first time through solid-state NMR analysis using stable isotope-labeled samples. Then it outlines design criteria for small-diameter SF-based vascular grafts, focusing on fabrication methods like electrospinning. Special attention is given to knitted SF grafts with SF sponge coatings, analyzed via
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Registered trials
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