A Remarkable Selectivity Observed in Hetero-Diels-Alder Reactions of Levoglucosenone (LGO) with Thiochalcones: An Experimental and Computational Study.

Grzegorz Mlostoń, Katarzyna Urbaniak, Marcin Palusiak, Ernst-Ulrich Würthwein, Hans-Ulrich Reissig, Zbigniew J Witczak

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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5 · Who and what money

Authors and funding

6 authors.

Grzegorz MlostońDepartment of Organic and Applied Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, PL-91-403 Lodz, Poland.ORCID 0000-0003-3631-3239

Katarzyna UrbaniakDepartment of Organic and Applied Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, PL-91-403 Lodz, Poland.

Marcin PalusiakDepartment of Physical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163/165, PL-90-236 Lodz, Poland.ORCID 0000-0002-0032-0878

Ernst-Ulrich WürthweinOrganisch-Chemisches Institut and Center for Multiscale Theory and Computation (CMTC), Universität Münster, Corrensstrasse 40, D-48149 Münster, Germany.ORCID 0000-0003-1327-3721

Hans-Ulrich ReissigInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, D-14195 Berlin, Germany.

Zbigniew J WitczakDepartment of Pharmaceutical Sciences, Nesbitt School of Pharmacy, Wilkes University, 84 W. South Street, Wilkes-Barre, PA 18766, USA.ORCID 0000-0003-3310-6808

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Levoglucosenone (LGO) smoothly undergoes microwave-assisted hetero-Diels-Alder reactions with thiochalcones in THF solution at 60 °C. The studied reactions are completed after 10 min, and the expected tricyclic 2,3-dihydro-4

Indexed as

DFT calculationshetero-Diels–Alder reactionslevoglucosenonesingle crystal X-ray analysissulfur heterocyclesthiochalcones

Identifiers

PMID41011674

DOI10.3390/molecules30183783

PMCPMC12472878

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