Comparative Antioxidant Protection of Cochlear Hair Cells from Ototoxins.

Allen F Ryan, Kwang Pak, Eun Jung Lee, Arwa Kurabi

Abstract readComparative Study

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Allen F RyanDepartment of Otolaryngology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-9894-8083

Kwang PakDepartment of Otolaryngology, University of California San Diego, La Jolla, CA 92093, USA.

Eun Jung LeeDepartment of Otolaryngology, University of California San Diego, La Jolla, CA 92093, USA.

Arwa KurabiDepartment of Otolaryngology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-5765-9496

Funding

BLRD VA I01 BX001205San Diego VA BX001205

6 · The paper itself

Abstract

Many forms of damage to cochlear sensory cells involve reactive oxygen species (ROS). We previously screened 81 antioxidants in vitro for the ability to reduce cochlear hair cell (HC) damage by the ototoxic aminoglycoside gentamicin. Only 13 antioxidants produced significant reduction in HC loss, with the quinone antioxidants seratrodast and idebenone being most protective. Why so few antioxidants were protective is unclear, but most antioxidants have other properties that could enhance or detract from protection. In particular, seratrodast is a potent thromboxane A

Indexed as

Bridged Bicyclo Compounds, HeterocyclicCochleaFatty Acids, UnsaturatedFree Radical ScavengersHair Cells, AuditoryHydrazinesNeuroprotectionNeuroprotective AgentsOtotoxicityProstaglandin AntagonistsReceptors, Thromboxane A2, Prostaglandin H2AnimalsAnti-Bacterial AgentsAntineoplastic AgentsBenzoquinonesCisplatinAnti-Bacterial AgentsAntineoplastic AgentsBenzoquinonesBridged Bicyclo Compounds, HeterocyclicCisplatinFatty Acids, UnsaturatedFree Radical ScavengersGentamicinsHeptanoic AcidsHomeodomain ProteinsHydrazinesidebenoneNeuroprotective AgentsPou4f3 protein, mouseProstaglandin AntagonistsReactive Oxygen SpeciesReceptors, Thromboxane A2, Prostaglandin H2seratrodastSQ 29548Transcription Factor Brn-3CUbiquinonecisplatincochlear damagehair cell protectioninner ear

Identifiers

PMID41011663

DOI10.3390/molecules30183772

PMCPMC12473111

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.