Evidence map›Paper›PMID 41011645›Full record

ArticleMolecules (Basel, Switzerland)2025

Rosmarinosin A Inhibits Inflammatory Response in Lipopolysaccharide-Induced RAW 264.7 Macrophages via Suppressing NF-κB and MAPK Signaling Pathway.

Hanui Lee, Gyeong Han Jeong, Seung Sik Lee, Kyung-Bon Lee, Sanghwa Park, Tae Hoon Kim, Hyoung-Woo Bai, Byung Yeoup Chung

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Mature-StageInternational journal of molecular sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hanui LeeAdvanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup 56212, Republic of Korea.
Gyeong Han JeongAdvanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup 56212, Republic of Korea.
Seung Sik LeeAdvanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup 56212, Republic of Korea.
Kyung-Bon LeeDepartment of Biology Education, Chonnam National University, Gwangju 61186, Republic of Korea.
Sanghwa ParkBio-Resources Bank Division, Nakdonggang National Institute of Biological Resources (NNIBR), Sangju 37242, Republic of Korea.ORCID 0000-0002-9130-0724
Tae Hoon KimDepartment of Food Science and Biotechnology, Daegu University, Gyeongsan 38453, Republic of Korea.
Hyoung-Woo BaiAdvanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup 56212, Republic of Korea.ORCID 0000-0002-1122-171X
Byung Yeoup ChungAdvanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup 56212, Republic of Korea.

Funding

National Research Foundation of Korea RS-2025-02613113
6 · The paper itself

Abstract

In the present study, we investigated the mechanisms underlying the anti-inflammatory effects of rosmarinosin A in (LPS)-stimulated RAW 264.7 macrophages. The cells were pretreated with various concentrations of rosmarinosin A, and then stimulated with LPS. Rosmarinosin A reduced the production of nitric oxide (NO) and prostaglandin E

Indexed as

Anti-Inflammatory AgentsInflammationLipopolysaccharidesMacrophagesMAP Kinase Signaling SystemNF-kappa BAnimalsCyclooxygenase 2CytokinesDinoprostoneMiceNitric OxideNitric Oxide Synthase Type IIRAW 264.7 CellsSignal TransductionAnti-Inflammatory AgentsCyclooxygenase 2CytokinesDinoprostoneLipopolysaccharidesNF-kappa BNitric OxideNitric Oxide Synthase Type IIanti-inflammatorydimeric phenylpropanoidMAPKNF-κBrosmarinosin A

Identifiers

PMID41011645
PMCPMC12472359

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.