ArticleMolecules (Basel, Switzerland)2025
Synthesis, Clastogenic and Cytotoxic Potential, and In Vivo Antitumor Activity of a Novel N-Mustard Based on Indole-3-carboxylic Acid Derivative.
Marina Filimonova, Olga Soldatova, Anna Shitova, Valentina Surinova, Vitaly Rybachuk, Alexander Kosachenko, Kirill Nikolaev, Daria Filatova, Ekaterina Prosovskaya, Sergey Ivanov and 3 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Marina FilimonovaA. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.ORCID 0000-0002-9690-4746 Olga SoldatovaA. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.ORCID 0000-0002-1178-3560 Anna ShitovaA. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.ORCID 0000-0001-5512-9096 Valentina SurinovaA. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Vitaly RybachukA. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.ORCID 0000-0001-8820-9965 Alexander KosachenkoA. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.ORCID 0000-0003-2173-388X Kirill NikolaevA. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.ORCID 0000-0003-0518-8228 Daria FilatovaA. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Ekaterina ProsovskayaA. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Sergey IvanovA. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Petr ShegayNational Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Andrey KaprinNational Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Alexander FilimonovA. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.ORCID 0000-0002-4398-1764 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Compound T1089-a novel nitrogen mustard based on an indole-3-carboxylic acid derivative (ICAD)-has been synthesized. The ICAD used as the basis for T1089 is a TLR agonist capable of activating an antitumor immune response. This study describes the synthesis method and presents the results of preliminary investigations of this compound. This research included an assessment of acute toxicity in mice, in vivo clastogenic activity evaluated via the bone marrow chromosome aberration (BMCA) test in mice, in vitro cytotoxicity determined by the MTT assay against human lung carcinoma A549 cells, and in vivo antitumor effects (ATEs) in models of conventional chemotherapy (CCT) of solid tumors in mice. The bifunctional alkylating agent cyclophosphamide (CPA) was used as a reference drug.
Indexed as
Antineoplastic AgentsIndolesA549 CellsAnimalsChromosome AberrationsCyclophosphamideHumansMiceAntineoplastic AgentsCyclophosphamideIndolesalkylating agentantitumor effectclastogenic effectconventional chemotherapycytotoxic effectindole-3-carboxylic acid derivativemetronomic chemotherapynitrogen mustardTLR agonist
Identifiers
PMID41011603
PMCPMC12472313
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390